Molecular Profiling of Immunotherapeutic Resistance

Davide Bedognetti, Ena Wang, Marimo Sato-Matsushita, Francesco M. Marincola, Maria Libera Ascierto

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

During the last few years several immunotherapies have been shown to induce clinical response and/or improve the clinical outcome in a significant number of cancer patients. However, the lack of a human-centered translational approach has led to the accumulation of a multitude of disjointed clinical and basic researches with a consequent disharmonic growth of the scientific knowledge. The huge number of non-evidence-based conjectural hypotheses has competitively interacted with the few evidence-based hypotheses generated by studies conducted in humans leading to the accumulation of several clinical breakdowns and few "mysterious" successes.In the last decade, the availability of high-throughput gene expression profiling has led to the development of novel discovery-driven approaches capable of investigating the tumor/host integration in its globality. Here, we describe in detail gene expression profiling studies that have led to the formulation of a new generation of evidence-based hypotheses explaining the structural basis of the immune-mediated tumor rejection following immunotherapy.

Original languageEnglish
Title of host publicationCancer Immunotherapy: Immune Suppression and Tumor Growth: Second Edition
PublisherElsevier Inc.
Pages373-394
Number of pages22
ISBN (Print)9780123942968
DOIs
Publication statusPublished - Jul 2013
Externally publishedYes

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Keywords

  • Adoptive therapy
  • Bedside to bench and back
  • Biomarker
  • CCR5
  • Chemokine
  • CXCR3
  • Gene expression profiling
  • Gene signature
  • High-throughput technology
  • Immunologic constant of rejection
  • Immunotherapy
  • Interferon signaling
  • Interleukin-2
  • Microarray
  • Vaccine therapy

ASJC Scopus subject areas

  • Medicine(all)
  • Dentistry(all)

Cite this

Bedognetti, D., Wang, E., Sato-Matsushita, M., Marincola, F. M., & Ascierto, M. L. (2013). Molecular Profiling of Immunotherapeutic Resistance. In Cancer Immunotherapy: Immune Suppression and Tumor Growth: Second Edition (pp. 373-394). Elsevier Inc.. https://doi.org/10.1016/B978-0-12-394296-8.00023-3