Molecular Mechanisms Linking Oxidative Stress and Diabetes Mellitus

Habib Yaribeygi, Thozhukat Sathyapalan, Stephen L. Atkin, Amirhossein Sahebkar

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Type 2 diabetes mellitus (T2DM) is the most prevalent metabolic disorder characterized by chronic hyperglycemia and an inadequate response to circulatory insulin by peripheral tissues resulting in insulin resistance. Insulin resistance has a complex pathophysiology, and it is contributed to by multiple factors including oxidative stress. Oxidative stress refers to an imbalance between free radical production and the antioxidant system leading to a reduction of peripheral insulin sensitivity and contributing to the development of T2DM via several molecular mechanisms. In this review, we present the molecular mechanisms by which the oxidative milieu contributes to the pathophysiology of insulin resistance and diabetes mellitus.

Original languageEnglish
Article number8609213
JournalOxidative Medicine and Cellular Longevity
Publication statusPublished - 1 Jan 2020


ASJC Scopus subject areas

  • Biochemistry
  • Ageing
  • Cell Biology

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