Molecular mechanisms by which aerobic exercise induces insulin sensitivity

Habib Yaribeygi, Stephen Atkin, Luis E. Simental-Mendía, Amirhossein Sahebkar

Research output: Contribution to journalArticle

7 Citations (Scopus)


Insulin resistance is a key feature of Type 2 diabetes and an important therapeutic target to address glycemic control to prevent diabetic complications. Lifestyle advice is the first step in the ADA/EASD consensus guidelines followed by metformin therapy. Aerobic exercise (AE) can increase insulin sensitivity by several molecular pathways including upregulation of insulin transporters in the cellular membrane of insulin-dependent cells. In addition, AE improves insulin sensitivity by amelioration of the pathophysiologic pathways involved in insulin resistance such as the reduction of adipokines, inflammatory and oxidative stress responses, and improvement of insulin signal transduction via different molecular pathways. This review details the molecular pathways by which AE induces beneficial effects on insulin resistance.

Original languageEnglish
JournalJournal of Cellular Physiology
Publication statusAccepted/In press - 1 Jan 2019



  • adipokines
  • aerobic exercise
  • inflammation
  • insulin resistance
  • insulin signal transduction
  • oxidative stress

ASJC Scopus subject areas

  • Physiology
  • Clinical Biochemistry
  • Cell Biology

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