Molecular immune signatures of HIV-1 vaccines in human PBMCs

Alessandro Monaco, Francesco M. Marincola, Marianna Sabatino, Zoltan Pos, Maria Lina Tornesello, David F. Stroncek, Ena Wang, George K. Lewis, Franco M. Buonaguro, Luigi Buonaguro

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

The global transcriptional profile of peripheral blood mononuclear cells (PBMCs) stimulated with HIV candidate vaccine (virus-like particles, VLPs) has been evaluated in HIV-infected patients with low/high viral load compared to healthy volunteers. Baseline activation of chemokine production was observed in PBMC from HIV-infected patients and innate immune stimulation with HIV-VLPs was not blunted. The immune profile among HIV-infected patients was found to be qualitatively similar but quantitatively extremely variable. This diversity was independent of viral load and it might be dependent on individual immunogenetic traits or concurrent immunological status. This ex vivo screening strategy represents an efficient tool for guiding modifications/optimizations of vaccination strategies and understanding failures in individuals enrolled in clinical trials.

Original languageEnglish
Pages (from-to)3004-3008
Number of pages5
JournalFEBS Letters
Volume583
Issue number18
DOIs
Publication statusPublished - 17 Sep 2009
Externally publishedYes

Fingerprint

AIDS Vaccines
HIV-1
Blood Cells
Blood
Virus-Like Particle Vaccines
Vaccines
HIV
Viral Load
Viruses
Chemokines
Virion
Screening
Chemical activation
Immunogenetics
Healthy Volunteers
Vaccination
Clinical Trials

Keywords

  • HIV-1
  • Immunogenomics
  • Peripheral blood mononuclear cell
  • Vaccine

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Cell Biology
  • Genetics
  • Molecular Biology
  • Structural Biology

Cite this

Monaco, A., Marincola, F. M., Sabatino, M., Pos, Z., Tornesello, M. L., Stroncek, D. F., ... Buonaguro, L. (2009). Molecular immune signatures of HIV-1 vaccines in human PBMCs. FEBS Letters, 583(18), 3004-3008. https://doi.org/10.1016/j.febslet.2009.07.060

Molecular immune signatures of HIV-1 vaccines in human PBMCs. / Monaco, Alessandro; Marincola, Francesco M.; Sabatino, Marianna; Pos, Zoltan; Tornesello, Maria Lina; Stroncek, David F.; Wang, Ena; Lewis, George K.; Buonaguro, Franco M.; Buonaguro, Luigi.

In: FEBS Letters, Vol. 583, No. 18, 17.09.2009, p. 3004-3008.

Research output: Contribution to journalArticle

Monaco, A, Marincola, FM, Sabatino, M, Pos, Z, Tornesello, ML, Stroncek, DF, Wang, E, Lewis, GK, Buonaguro, FM & Buonaguro, L 2009, 'Molecular immune signatures of HIV-1 vaccines in human PBMCs', FEBS Letters, vol. 583, no. 18, pp. 3004-3008. https://doi.org/10.1016/j.febslet.2009.07.060
Monaco A, Marincola FM, Sabatino M, Pos Z, Tornesello ML, Stroncek DF et al. Molecular immune signatures of HIV-1 vaccines in human PBMCs. FEBS Letters. 2009 Sep 17;583(18):3004-3008. https://doi.org/10.1016/j.febslet.2009.07.060
Monaco, Alessandro ; Marincola, Francesco M. ; Sabatino, Marianna ; Pos, Zoltan ; Tornesello, Maria Lina ; Stroncek, David F. ; Wang, Ena ; Lewis, George K. ; Buonaguro, Franco M. ; Buonaguro, Luigi. / Molecular immune signatures of HIV-1 vaccines in human PBMCs. In: FEBS Letters. 2009 ; Vol. 583, No. 18. pp. 3004-3008.
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