Molecular classification of nemaline myopathies: "Nontyping" specimens exhibit unique patterns of gene expression

Despina Sanoudou, Leslie A. Frieden, Judith N. Haslett, Alvin T. Kho, Steven A. Greenberg, Isaac S. Kohane, Louis M. Kunkel, Alan H. Beggs

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Nemaline myopathy (NM) is a slowly progressive or nonprogressive neuromuscular disorder caused by mutations in genes encoding skeletal muscle sarcomeric thin filament proteins. It is characterized by great heterogeneity at the clinical, histopathological, and genetic level. Although multiple molecular pathways are commonly affected in all NM patients, little is known about the molecular characteristics of muscles from patients in different NM subgroups. We have analyzed a group of global gene expression data sets for transcriptional patterns characteristic of particular nemaline myopathy classes. Differential expression between disease subgroups was primarily seen in mitochondrial-, structural-, and transcription-related genes. Multiple lines of evidence support the hypothesis that muscles from cases with "nontyping" NM, although clinically classified as typical NM, share a unique pathophysiological state and are characterized by distinct patterns of gene expression. Determination of the specific molecular differences in NM subgroups may eventually lead to improved prognostic determinations and treatment of these patients.

Original languageEnglish
Pages (from-to)590-600
Number of pages11
JournalNeurobiology of Disease
Volume15
Issue number3
DOIs
Publication statusPublished - 1 Apr 2004
Externally publishedYes

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Keywords

  • Gene expression
  • Microarrays
  • Nemaline myopathy
  • Neuromuscular disease
  • Skeletal muscle
  • Troponin T

ASJC Scopus subject areas

  • Neurology

Cite this

Sanoudou, D., Frieden, L. A., Haslett, J. N., Kho, A. T., Greenberg, S. A., Kohane, I. S., Kunkel, L. M., & Beggs, A. H. (2004). Molecular classification of nemaline myopathies: "Nontyping" specimens exhibit unique patterns of gene expression. Neurobiology of Disease, 15(3), 590-600. https://doi.org/10.1016/j.nbd.2003.12.013