Molecular basis of human hypertension: Role of angiotensinogen

Xavier Jeunemaitre, Florent Soubrier, Yuri V. Kotelevtsev, Richard P. Lifton, Christopher S. Williams, Anne Charru, Steven Hunt, Paul N. Hopkins, Roger R. Williams, Jean Marc Lalouel, Pierre Corvol

Research output: Contribution to journalArticle

1644 Citations (Scopus)

Abstract

Essential hypertension is a common human disease believed to result from the interplay of multiple genetic and environmental determinants. In genetic studies of two large panels of hypertensive sibships from widely separated geographical areas, we obtained evidence of genetic linkage between the angiotensinogen gene (AGT) and hypertension, demonstrated association of AGT molecular variants with the disease, and found significant differences in plasma concentrations of angiotensinogen among hypertensive subjects with different AGT genotypes. The corroboration and replication afforded by these results support the interpretation that molecular variants of AGT constitute inherited predispositions to essential hypertension in humans.

Original languageEnglish
Pages (from-to)169-180
Number of pages12
JournalCell
Volume71
Issue number1
DOIs
Publication statusPublished - 2 Oct 1992
Externally publishedYes

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Angiotensinogen
Hypertension
Genes
Genetic Linkage
Genotype
Plasmas

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Biology

Cite this

Jeunemaitre, X., Soubrier, F., Kotelevtsev, Y. V., Lifton, R. P., Williams, C. S., Charru, A., ... Corvol, P. (1992). Molecular basis of human hypertension: Role of angiotensinogen. Cell, 71(1), 169-180. https://doi.org/10.1016/0092-8674(92)90275-H

Molecular basis of human hypertension : Role of angiotensinogen. / Jeunemaitre, Xavier; Soubrier, Florent; Kotelevtsev, Yuri V.; Lifton, Richard P.; Williams, Christopher S.; Charru, Anne; Hunt, Steven; Hopkins, Paul N.; Williams, Roger R.; Lalouel, Jean Marc; Corvol, Pierre.

In: Cell, Vol. 71, No. 1, 02.10.1992, p. 169-180.

Research output: Contribution to journalArticle

Jeunemaitre, X, Soubrier, F, Kotelevtsev, YV, Lifton, RP, Williams, CS, Charru, A, Hunt, S, Hopkins, PN, Williams, RR, Lalouel, JM & Corvol, P 1992, 'Molecular basis of human hypertension: Role of angiotensinogen', Cell, vol. 71, no. 1, pp. 169-180. https://doi.org/10.1016/0092-8674(92)90275-H
Jeunemaitre X, Soubrier F, Kotelevtsev YV, Lifton RP, Williams CS, Charru A et al. Molecular basis of human hypertension: Role of angiotensinogen. Cell. 1992 Oct 2;71(1):169-180. https://doi.org/10.1016/0092-8674(92)90275-H
Jeunemaitre, Xavier ; Soubrier, Florent ; Kotelevtsev, Yuri V. ; Lifton, Richard P. ; Williams, Christopher S. ; Charru, Anne ; Hunt, Steven ; Hopkins, Paul N. ; Williams, Roger R. ; Lalouel, Jean Marc ; Corvol, Pierre. / Molecular basis of human hypertension : Role of angiotensinogen. In: Cell. 1992 ; Vol. 71, No. 1. pp. 169-180.
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