Molecular basis of human hypertension: Role of angiotensinogen

Xavier Jeunemaitre, Florent Soubrier, Yuri V. Kotelevtsev, Richard P. Lifton, Christopher S. Williams, Anne Charru, Steven C. Hunt, Paul N. Hopkins, Roger R. Williams, Jean Marc Lalouel, Pierre Corvol

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Abstract

Essential hypertension is a common human disease believed to result from the interplay of multiple genetic and environmental determinants. In genetic studies of two large panels of hypertensive sibships from widely separated geographical areas, we obtained evidence of genetic linkage between the angiotensinogen gene (AGT) and hypertension, demonstrated association of AGT molecular variants with the disease, and found significant differences in plasma concentrations of angiotensinogen among hypertensive subjects with different AGT genotypes. The corroboration and replication afforded by these results support the interpretation that molecular variants of AGT constitute inherited predispositions to essential hypertension in humans.

Original languageEnglish
Pages (from-to)169-180
Number of pages12
JournalCell
Volume71
Issue number1
DOIs
Publication statusPublished - 2 Oct 1992

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ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Jeunemaitre, X., Soubrier, F., Kotelevtsev, Y. V., Lifton, R. P., Williams, C. S., Charru, A., Hunt, S. C., Hopkins, P. N., Williams, R. R., Lalouel, J. M., & Corvol, P. (1992). Molecular basis of human hypertension: Role of angiotensinogen. Cell, 71(1), 169-180. https://doi.org/10.1016/0092-8674(92)90275-H