Modulation of mRNA circadian transcription cycle by microRNAs

Andrey Ptitsyn, Natalia Ptitsyna, Emad Elsebakhi, Francesco Marincola, Rashid J. Al-Ali, Ramzi Temanni, Rawan T. Al Saad, Ena Wang

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Citation (Scopus)

Abstract

MicroRNAs are important modulators of gene expression. There is anecdotal evidence that the abundance of some microRNAs varies in circadian or approximately daily rhythm. In this study, using publicly available data we attempt a systematic analysis of co-expression between microRNAs and their prospective mRNA targets. An advanced analysis of periodicity with the application of digital filters in phase continuum revealed a baseline rhythmic oscillation on over 80% of both mRNA and microRNA populations. This computational observation adds evidence to the theory that microRNAs play an active role in modulation of rhythmic expression as a general rule rather than special exemption. We also explore the immediate implications of inferred oscillatory behavior for modeling of mRNA-miRNA dynamics.

Original languageEnglish
Title of host publication2014 Middle East Conference on Biomedical Engineering, MECBME 2014
PublisherIEEE Computer Society
Pages180-183
Number of pages4
ISBN (Print)9781479947997
DOIs
Publication statusPublished - 2014
Event2014 2nd Middle East Conference on Biomedical Engineering, MECBME 2014 - Doha, Qatar
Duration: 17 Feb 201420 Feb 2014

Other

Other2014 2nd Middle East Conference on Biomedical Engineering, MECBME 2014
CountryQatar
CityDoha
Period17/2/1420/2/14

Fingerprint

Transcription
Modulation
Digital filters
Gene expression
Modulators
Messenger RNA

ASJC Scopus subject areas

  • Biomedical Engineering

Cite this

Ptitsyn, A., Ptitsyna, N., Elsebakhi, E., Marincola, F., Al-Ali, R. J., Temanni, R., ... Wang, E. (2014). Modulation of mRNA circadian transcription cycle by microRNAs. In 2014 Middle East Conference on Biomedical Engineering, MECBME 2014 (pp. 180-183). [6783235] IEEE Computer Society. https://doi.org/10.1109/MECBME.2014.6783235

Modulation of mRNA circadian transcription cycle by microRNAs. / Ptitsyn, Andrey; Ptitsyna, Natalia; Elsebakhi, Emad; Marincola, Francesco; Al-Ali, Rashid J.; Temanni, Ramzi; Al Saad, Rawan T.; Wang, Ena.

2014 Middle East Conference on Biomedical Engineering, MECBME 2014. IEEE Computer Society, 2014. p. 180-183 6783235.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Ptitsyn, A, Ptitsyna, N, Elsebakhi, E, Marincola, F, Al-Ali, RJ, Temanni, R, Al Saad, RT & Wang, E 2014, Modulation of mRNA circadian transcription cycle by microRNAs. in 2014 Middle East Conference on Biomedical Engineering, MECBME 2014., 6783235, IEEE Computer Society, pp. 180-183, 2014 2nd Middle East Conference on Biomedical Engineering, MECBME 2014, Doha, Qatar, 17/2/14. https://doi.org/10.1109/MECBME.2014.6783235
Ptitsyn A, Ptitsyna N, Elsebakhi E, Marincola F, Al-Ali RJ, Temanni R et al. Modulation of mRNA circadian transcription cycle by microRNAs. In 2014 Middle East Conference on Biomedical Engineering, MECBME 2014. IEEE Computer Society. 2014. p. 180-183. 6783235 https://doi.org/10.1109/MECBME.2014.6783235
Ptitsyn, Andrey ; Ptitsyna, Natalia ; Elsebakhi, Emad ; Marincola, Francesco ; Al-Ali, Rashid J. ; Temanni, Ramzi ; Al Saad, Rawan T. ; Wang, Ena. / Modulation of mRNA circadian transcription cycle by microRNAs. 2014 Middle East Conference on Biomedical Engineering, MECBME 2014. IEEE Computer Society, 2014. pp. 180-183
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