Modulation of mRNA circadian transcription cycle by microRNAs

Andrey Ptitsyn, Natalia Ptitsyna, Emad Elsebakhi, Francesco Marincola, Rashid Al-Ali, M. Ramzi Temanni, Rawan Alsaad, Ena Wang

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Citation (Scopus)

Abstract

MicroRNAs are important modulators of gene expression. There is anecdotal evidence that the abundance of some microRNAs varies in circadian or approximately daily rhythm. In this study, using publicly available data we attempt a systematic analysis of co-expression between microRNAs and their prospective mRNA targets. An advanced analysis of periodicity with the application of digital filters in phase continuum revealed a baseline rhythmic oscillation on over 80% of both mRNA and microRNA populations. This computational observation adds evidence to the theory that microRNAs play an active role in modulation of rhythmic expression as a general rule rather than special exemption. We also explore the immediate implications of inferred oscillatory behavior for modeling of mRNA-miRNA dynamics.

Original languageEnglish
Title of host publication2014 Middle East Conference on Biomedical Engineering, MECBME 2014
PublisherIEEE Computer Society
Pages180-183
Number of pages4
ISBN (Print)9781479947997
DOIs
Publication statusPublished - 1 Jan 2014
Event2014 2nd Middle East Conference on Biomedical Engineering, MECBME 2014 - Doha, Qatar
Duration: 17 Feb 201420 Feb 2014

Publication series

NameMiddle East Conference on Biomedical Engineering, MECBME
ISSN (Print)2165-4247
ISSN (Electronic)2165-4255

Other

Other2014 2nd Middle East Conference on Biomedical Engineering, MECBME 2014
CountryQatar
CityDoha
Period17/2/1420/2/14

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ASJC Scopus subject areas

  • Biomedical Engineering

Cite this

Ptitsyn, A., Ptitsyna, N., Elsebakhi, E., Marincola, F., Al-Ali, R., Temanni, M. R., Alsaad, R., & Wang, E. (2014). Modulation of mRNA circadian transcription cycle by microRNAs. In 2014 Middle East Conference on Biomedical Engineering, MECBME 2014 (pp. 180-183). [6783235] (Middle East Conference on Biomedical Engineering, MECBME). IEEE Computer Society. https://doi.org/10.1109/MECBME.2014.6783235