This paper focuses on the modelling of communication channel noise inside human tissues at the THz band (0.1-10THz). A novel model is put forward based on the study of the physical mechanism of the channel noise in the medium, which takes into account both the radiation of the medium and the molecular absorption from the transmitted signal. The derivation and the general concepts of the noise modelling is detailed in the paper. The results show that the channel noise power spectral density at the scale of several micrometres is at acceptable levels and the value tends to decrease with the increase of both distance and frequency. In addition, the channel noise is also related to the composition of the human tissues, with the result of higher channel noise in tissues with higher water concentration. The conclusion drawn from the conducted study and analysis paves the way for more comprehensive characterisation of the electromagnetic channel within in-vivo nano-networks.