Modeling abnormal priming in Alzheimer's patients with a free association network

Javier Borge-Holthoefer, Yamir Moreno, Alex Arenas

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Alzheimer's Disease irremediably alters the proficiency of word search and retrieval processes even at its early stages. Such disruption can sometimes be paradoxical in specific language tasks, for example semantic priming. Here we focus in the striking side-effect of hyperpriming in Alzheimer's Disease patients, which has been well-established in the literature for a long time. Previous studies have evidenced that modern network theory can become a powerful complementary tool to gain insight in cognitive phenomena. Here, we first show that network modeling is an appropriate approach to account for semantic priming in normal subjects. Then we turn to priming in degraded cognition: hyperpriming can be readily understood in the scope of a progressive degradation of the semantic network structure. We compare our simulation results with previous empirical observations in diseased patients finding a qualitative agreement. The network approach presented here can be used to accommodate current theories about impaired cognition, and towards a better understanding of lexical organization in healthy and diseased patients.

Original languageEnglish
Article numbere22651
JournalPLoS One
Volume6
Issue number8
DOIs
Publication statusPublished - 4 Aug 2011
Externally publishedYes

Fingerprint

Free Association
Semantics
Association reactions
Alzheimer disease
cognition
Cognition
Alzheimer Disease
Circuit theory
Language
adverse effects
Degradation
degradation

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Modeling abnormal priming in Alzheimer's patients with a free association network. / Borge-Holthoefer, Javier; Moreno, Yamir; Arenas, Alex.

In: PLoS One, Vol. 6, No. 8, e22651, 04.08.2011.

Research output: Contribution to journalArticle

Borge-Holthoefer, Javier ; Moreno, Yamir ; Arenas, Alex. / Modeling abnormal priming in Alzheimer's patients with a free association network. In: PLoS One. 2011 ; Vol. 6, No. 8.
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