Model-fitting and linkage analysis of sodium-lithium countertransport

Sandra J. Hasstedt, Nicola J. Camp, Paul N. Hopkins, Hilary Coon, Jason T. McKinney, Richard M. Cawthon, Steven Hunt

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Increased sodium-lithium countertransport activity (SLC) associates with hypertension and is highly heritable, yet the underlying genes remain unknown. SLC, measured on 1113 and remeasured 2-3 years later on 675 adult members of 48 Utah pedigrees, was tested for candidate gene association, major locus inheritance, and linkage to genome scan markers using a bivariate model with genotype-specific effects of age, body mass index (BMI), and triglycerides level (TG). No effect of the α-adducin Gly460Trp polymorphism on SLC was found. In contrast, SLC increased with age in carriers of apolipoproteinE E2 (85 individuals; 8.7% of the sample) and decreased in noncarriers. Model-fitting analyses inferred two additional loci with genotype-specific responses to BMI and TG. Using the inferred model, lod scores >2 were obtained for D3S3038, D11S4464, and D10S677 for the BMI-responsive locus, and for D8S1048 for the TG-responsive locus.

Original languageEnglish
Pages (from-to)1055-1061
Number of pages7
JournalEuropean Journal of Human Genetics
Volume12
Issue number12
DOIs
Publication statusPublished - Dec 2004
Externally publishedYes

Fingerprint

Lithium
Sodium
Triglycerides
Body Mass Index
Genotype
Lod Score
Pedigree
Genes
Genome
Hypertension

Keywords

  • Genetics
  • Likelihood analysis
  • Linkage analysis

ASJC Scopus subject areas

  • Genetics(clinical)

Cite this

Hasstedt, S. J., Camp, N. J., Hopkins, P. N., Coon, H., McKinney, J. T., Cawthon, R. M., & Hunt, S. (2004). Model-fitting and linkage analysis of sodium-lithium countertransport. European Journal of Human Genetics, 12(12), 1055-1061. https://doi.org/10.1038/sj.ejhg.5201262

Model-fitting and linkage analysis of sodium-lithium countertransport. / Hasstedt, Sandra J.; Camp, Nicola J.; Hopkins, Paul N.; Coon, Hilary; McKinney, Jason T.; Cawthon, Richard M.; Hunt, Steven.

In: European Journal of Human Genetics, Vol. 12, No. 12, 12.2004, p. 1055-1061.

Research output: Contribution to journalArticle

Hasstedt, SJ, Camp, NJ, Hopkins, PN, Coon, H, McKinney, JT, Cawthon, RM & Hunt, S 2004, 'Model-fitting and linkage analysis of sodium-lithium countertransport', European Journal of Human Genetics, vol. 12, no. 12, pp. 1055-1061. https://doi.org/10.1038/sj.ejhg.5201262
Hasstedt SJ, Camp NJ, Hopkins PN, Coon H, McKinney JT, Cawthon RM et al. Model-fitting and linkage analysis of sodium-lithium countertransport. European Journal of Human Genetics. 2004 Dec;12(12):1055-1061. https://doi.org/10.1038/sj.ejhg.5201262
Hasstedt, Sandra J. ; Camp, Nicola J. ; Hopkins, Paul N. ; Coon, Hilary ; McKinney, Jason T. ; Cawthon, Richard M. ; Hunt, Steven. / Model-fitting and linkage analysis of sodium-lithium countertransport. In: European Journal of Human Genetics. 2004 ; Vol. 12, No. 12. pp. 1055-1061.
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