Model-fitting and linkage analysis of sodium-lithium countertransport

Sandra J. Hasstedt, Nicola J. Camp, Paul N. Hopkins, Hilary Coon, Jason T. McKinney, Richard M. Cawthon, Steven C. Hunt

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4 Citations (Scopus)

Abstract

Increased sodium-lithium countertransport activity (SLC) associates with hypertension and is highly heritable, yet the underlying genes remain unknown. SLC, measured on 1113 and remeasured 2-3 years later on 675 adult members of 48 Utah pedigrees, was tested for candidate gene association, major locus inheritance, and linkage to genome scan markers using a bivariate model with genotype-specific effects of age, body mass index (BMI), and triglycerides level (TG). No effect of the α-adducin Gly460Trp polymorphism on SLC was found. In contrast, SLC increased with age in carriers of apolipoproteinE E2 (85 individuals; 8.7% of the sample) and decreased in noncarriers. Model-fitting analyses inferred two additional loci with genotype-specific responses to BMI and TG. Using the inferred model, lod scores >2 were obtained for D3S3038, D11S4464, and D10S677 for the BMI-responsive locus, and for D8S1048 for the TG-responsive locus.

Original languageEnglish
Pages (from-to)1055-1061
Number of pages7
JournalEuropean Journal of Human Genetics
Volume12
Issue number12
DOIs
Publication statusPublished - 1 Dec 2004

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Keywords

  • Genetics
  • Likelihood analysis
  • Linkage analysis

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

Cite this

Hasstedt, S. J., Camp, N. J., Hopkins, P. N., Coon, H., McKinney, J. T., Cawthon, R. M., & Hunt, S. C. (2004). Model-fitting and linkage analysis of sodium-lithium countertransport. European Journal of Human Genetics, 12(12), 1055-1061. https://doi.org/10.1038/sj.ejhg.5201262