Mitochondrial dysfunction in diabetes and the regulatory roles of antidiabetic agents on the mitochondrial function

Habib Yaribeygi, Stephen Atkin, Amirhossein Sahebkar

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

The prevalence of type 2 diabetes mellitus (T2DM) is increasing rapidly with its associated morbidity and mortality. Many pathophysiological pathways such as oxidative stress, inflammatory responses, adipokines, obesity-induced insulin resistance, improper insulin signaling, and beta cell apoptosis are associated with the development of T2DM. There is increasing evidence of the role of mitochondrial dysfunction in the onset of T2DM, particularly in relation to the development of diabetic complications. Here, the role of mitochondrial dysfunction in T2DM is reviewed together with its modulation by antidiabetic therapeutic agents, an effect that may be independent of their hypoglycemic effect.

Original languageEnglish
JournalJournal of Cellular Physiology
DOIs
Publication statusAccepted/In press - 1 Jan 2018

Fingerprint

Medical problems
Hypoglycemic Agents
Type 2 Diabetes Mellitus
Insulin
Adipokines
Oxidative stress
Therapeutic Uses
Diabetes Complications
Insulin Resistance
Oxidative Stress
Obesity
Modulation
Apoptosis
Morbidity
Mortality

Keywords

  • antidiabetic agents
  • diabetes mellitus
  • diabetic complications
  • mitochondria
  • mitochondrial dysfunction

ASJC Scopus subject areas

  • Physiology
  • Clinical Biochemistry
  • Cell Biology

Cite this

Mitochondrial dysfunction in diabetes and the regulatory roles of antidiabetic agents on the mitochondrial function. / Yaribeygi, Habib; Atkin, Stephen; Sahebkar, Amirhossein.

In: Journal of Cellular Physiology, 01.01.2018.

Research output: Contribution to journalArticle

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