Mining the mutanome: Developing highly personalized Immunotherapies based on mutational analysis of tumors

Willem W. Overwijk, Ena Wang, Francesco M. Marincola, Hans Georg Rammensee, Nicholas P. Restifo, Organizing Committee of the 2013 SITC Workshop on Personalized Immunotherapy

Research output: Contribution to journalReview article

44 Citations (Scopus)

Abstract

T cells can mediate remarkable tumor regressions including complete cure in patients with metastatic cancer. Genetic alterations in an individual's cancer cells (the mutanome) encode unique peptides (m-peptides) that can be targets for T cells. The recent advances in next-generation sequencing and computation prediction allows, for the first time, the rapid and affordable identification of m-peptides in individual patients. Despite excitement about the extended spectrum of potential targets in personalized immunotherapy, there is no experience or consensus on the path to their successful clinical application. Major questions remain, such as whether clinical responses to cytokine therapy, T cell transfer, and checkpoint blockade are primarily mediated by m-peptide-specific reactivity, whether m-peptides can be effectively used as vaccines, and which m-peptides are most potently recognized. These and other technological, immunological and translational questions will be explored during a 1-day Workshop on Personalized Cancer Immunotherapy by the Society for Immunotherapy of Cancer, directly before the Annual Meeting, on November 7, 2013 at the National Harbor, MD near Washington, DC.

Original languageEnglish
Article number11
JournalJournal for ImmunoTherapy of Cancer
Volume1
DOIs
Publication statusPublished - 2013
Externally publishedYes

    Fingerprint

Keywords

  • Checkpoint blockade
  • Exome
  • Mutanome
  • Mutation
  • Neoantigen
  • Next-generation sequencing
  • Omics
  • Peptide epitope
  • T lymphocyte
  • Vaccine

ASJC Scopus subject areas

  • Oncology
  • Immunology and Allergy
  • Cancer Research
  • Molecular Medicine
  • Pharmacology
  • Immunology

Cite this

Overwijk, W. W., Wang, E., Marincola, F. M., Rammensee, H. G., Restifo, N. P., & Organizing Committee of the 2013 SITC Workshop on Personalized Immunotherapy (2013). Mining the mutanome: Developing highly personalized Immunotherapies based on mutational analysis of tumors. Journal for ImmunoTherapy of Cancer, 1, [11]. https://doi.org/10.1186/2051-1426-1-11