Microvascular complications: Evaluation and monitoring relevance to clinical practice, clinical trials, and drug development

Adam Greenstein, Mitra Tavakoli, Moaz Mojaddidi, Ahmed Al-Sunni, Glenn Matfin, Rayaz Malik

Research output: Contribution to journalReview article

5 Citations (Scopus)

Abstract

The long-term microvascular complications of diabetes pose a major health burden. Although, much of the focus has been on the macrovascular complications, it is clear that the microvascular complications have a significant impact on both morbidity and mortality amongst diabetic patients. Indeed retinopathy, nephropathy, and neuropathy compete as the leading causes of premature blindness, end-stage renal disease, and non-traumatic lower-limb amputation, respectively. Furthermore, complications develop and progress in unison and indeed share many common risk factors. Effective evaluation and monitoring of these complications in clinical practice is clearly important, however, it is also relevant to clinical intervention studies, and drug development programs addressing microvascular complications. Novel diagnostic and therapeutic strategies are continually evolving in this area and will be discussed in more detail in this review.

Original languageEnglish
Pages (from-to)166-171
Number of pages6
JournalBritish Journal of Diabetes and Vascular Disease
Volume7
Issue number4
DOIs
Publication statusPublished - Jul 2007
Externally publishedYes

Fingerprint

Diabetes Complications
Blindness
Amputation
Chronic Kidney Failure
Lower Extremity
Clinical Trials
Morbidity
Mortality
Health
Pharmaceutical Preparations
Therapeutics
Clinical Studies

Keywords

  • Diagnosis
  • Nephropathy
  • Neuropathy
  • Retinopathy
  • Treatment

ASJC Scopus subject areas

  • Internal Medicine
  • Cardiology and Cardiovascular Medicine
  • Endocrinology, Diabetes and Metabolism

Cite this

Microvascular complications : Evaluation and monitoring relevance to clinical practice, clinical trials, and drug development. / Greenstein, Adam; Tavakoli, Mitra; Mojaddidi, Moaz; Al-Sunni, Ahmed; Matfin, Glenn; Malik, Rayaz.

In: British Journal of Diabetes and Vascular Disease, Vol. 7, No. 4, 07.2007, p. 166-171.

Research output: Contribution to journalReview article

Greenstein, Adam ; Tavakoli, Mitra ; Mojaddidi, Moaz ; Al-Sunni, Ahmed ; Matfin, Glenn ; Malik, Rayaz. / Microvascular complications : Evaluation and monitoring relevance to clinical practice, clinical trials, and drug development. In: British Journal of Diabetes and Vascular Disease. 2007 ; Vol. 7, No. 4. pp. 166-171.
@article{6f40bf3a65ef44f5a3f0b61cd9a4509d,
title = "Microvascular complications: Evaluation and monitoring relevance to clinical practice, clinical trials, and drug development",
abstract = "The long-term microvascular complications of diabetes pose a major health burden. Although, much of the focus has been on the macrovascular complications, it is clear that the microvascular complications have a significant impact on both morbidity and mortality amongst diabetic patients. Indeed retinopathy, nephropathy, and neuropathy compete as the leading causes of premature blindness, end-stage renal disease, and non-traumatic lower-limb amputation, respectively. Furthermore, complications develop and progress in unison and indeed share many common risk factors. Effective evaluation and monitoring of these complications in clinical practice is clearly important, however, it is also relevant to clinical intervention studies, and drug development programs addressing microvascular complications. Novel diagnostic and therapeutic strategies are continually evolving in this area and will be discussed in more detail in this review.",
keywords = "Diagnosis, Nephropathy, Neuropathy, Retinopathy, Treatment",
author = "Adam Greenstein and Mitra Tavakoli and Moaz Mojaddidi and Ahmed Al-Sunni and Glenn Matfin and Rayaz Malik",
year = "2007",
month = "7",
doi = "10.1177/14746514070070040501",
language = "English",
volume = "7",
pages = "166--171",
journal = "British Journal of Diabetes and Vascular Disease",
issn = "1474-6514",
publisher = "SAGE Publications Inc.",
number = "4",

}

TY - JOUR

T1 - Microvascular complications

T2 - Evaluation and monitoring relevance to clinical practice, clinical trials, and drug development

AU - Greenstein, Adam

AU - Tavakoli, Mitra

AU - Mojaddidi, Moaz

AU - Al-Sunni, Ahmed

AU - Matfin, Glenn

AU - Malik, Rayaz

PY - 2007/7

Y1 - 2007/7

N2 - The long-term microvascular complications of diabetes pose a major health burden. Although, much of the focus has been on the macrovascular complications, it is clear that the microvascular complications have a significant impact on both morbidity and mortality amongst diabetic patients. Indeed retinopathy, nephropathy, and neuropathy compete as the leading causes of premature blindness, end-stage renal disease, and non-traumatic lower-limb amputation, respectively. Furthermore, complications develop and progress in unison and indeed share many common risk factors. Effective evaluation and monitoring of these complications in clinical practice is clearly important, however, it is also relevant to clinical intervention studies, and drug development programs addressing microvascular complications. Novel diagnostic and therapeutic strategies are continually evolving in this area and will be discussed in more detail in this review.

AB - The long-term microvascular complications of diabetes pose a major health burden. Although, much of the focus has been on the macrovascular complications, it is clear that the microvascular complications have a significant impact on both morbidity and mortality amongst diabetic patients. Indeed retinopathy, nephropathy, and neuropathy compete as the leading causes of premature blindness, end-stage renal disease, and non-traumatic lower-limb amputation, respectively. Furthermore, complications develop and progress in unison and indeed share many common risk factors. Effective evaluation and monitoring of these complications in clinical practice is clearly important, however, it is also relevant to clinical intervention studies, and drug development programs addressing microvascular complications. Novel diagnostic and therapeutic strategies are continually evolving in this area and will be discussed in more detail in this review.

KW - Diagnosis

KW - Nephropathy

KW - Neuropathy

KW - Retinopathy

KW - Treatment

UR - http://www.scopus.com/inward/record.url?scp=34548473313&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=34548473313&partnerID=8YFLogxK

U2 - 10.1177/14746514070070040501

DO - 10.1177/14746514070070040501

M3 - Review article

AN - SCOPUS:34548473313

VL - 7

SP - 166

EP - 171

JO - British Journal of Diabetes and Vascular Disease

JF - British Journal of Diabetes and Vascular Disease

SN - 1474-6514

IS - 4

ER -