Microscopic magnetic resonance imaging reveals high prevalence of third coronary artery in human and rabbit heart

Rebecca A B Burton, Jürgen E. Schneider, Martin J. Bishop, Patrick W. Hales, Christian Bollensdorff, Matthew D. Robson, Kelvin C K Wong, John Morris, T. Alexander Quinn, Peter Kohl

Research output: Contribution to journalArticle

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Abstract

AimThe human coronary tree is commonly assumed to have two roots: the left and right coronary arteries (LCA and RCA, respectively). However, a third coronary artery (TCA) has been observed in humans and animals, usually arising from the right anterior aortic sinus near the RCA. Using high-resolution magnetic resonance imaging, we identified TCA prevalence and characteristics in rabbit and human hearts.Methods and resultsThird coronary artery presence was analysed in hearts from 11 New Zealand white rabbits and 7 human cadavers, using excised tissue that was fixed, gadolinium-treated, and agar-embedded for imaging-based reconstruction. A TCA was identified in all rabbit hearts and six of seven human hearts, originating either from an independent ostium (7 of 11 rabbits, 2 of 7 humans) or an ostium shared with the RCA (4 of 11 rabbits, 4 of 7 humans). Proximal TCA cross-sectional area in rabbits was 15.3 ± 6.0 of RCA area (mean ± SD, based on n 9 rabbit hearts in which reliable measurements could be taken for both vessels), and 26.7 ± 10.1 in humans (n 4). In all-but-one case where a TCA was observed, it originated ventral to the RCA, progressing towards the right ventricular outflow tract. In one rabbit, the TCA originated dorsal to the RCA and progressed towards the Crista terminalis in the right atrium. A fourth vessel, forming a separate aortic Vas vasorum was occasionally seen, originating from the right anterior aortic sinus either from an ostium common with (1 of 11 rabbits, 0 of 7 humans) or independent of (1 of 11 rabbits, 1 of 7 humans) the TCA. Pilot optical mapping experiments showed that TCA occlusion had variable acute effects on rabbit cardiac electrophysiology.ConclusionThird coronary artery presence is common in rabbit and human hearts. Functional effects of disrupted TCA blood supply are ill-investigated, and the rabbit may be a suitable species for such research.

Original languageEnglish
JournalEuropace
Volume14
Issue numberSUPPL. 5
DOIs
Publication statusPublished - 1 Nov 2012
Externally publishedYes

Fingerprint

Coronary Vessels
Magnetic Resonance Imaging
Rabbits
Sinus of Valsalva
Cardiac Electrophysiology
Coronary Occlusion
Gadolinium
Heart Atria
Cadaver
Agar

Keywords

  • Arrhythmia
  • Conus arteriosus
  • Coronary tree
  • Rabbit model
  • Right ventricular outflow tract
  • Third coronary artery

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

Cite this

Burton, R. A. B., Schneider, J. E., Bishop, M. J., Hales, P. W., Bollensdorff, C., Robson, M. D., ... Kohl, P. (2012). Microscopic magnetic resonance imaging reveals high prevalence of third coronary artery in human and rabbit heart. Europace, 14(SUPPL. 5). https://doi.org/10.1093/europace/eus276

Microscopic magnetic resonance imaging reveals high prevalence of third coronary artery in human and rabbit heart. / Burton, Rebecca A B; Schneider, Jürgen E.; Bishop, Martin J.; Hales, Patrick W.; Bollensdorff, Christian; Robson, Matthew D.; Wong, Kelvin C K; Morris, John; Quinn, T. Alexander; Kohl, Peter.

In: Europace, Vol. 14, No. SUPPL. 5, 01.11.2012.

Research output: Contribution to journalArticle

Burton, RAB, Schneider, JE, Bishop, MJ, Hales, PW, Bollensdorff, C, Robson, MD, Wong, KCK, Morris, J, Quinn, TA & Kohl, P 2012, 'Microscopic magnetic resonance imaging reveals high prevalence of third coronary artery in human and rabbit heart', Europace, vol. 14, no. SUPPL. 5. https://doi.org/10.1093/europace/eus276
Burton RAB, Schneider JE, Bishop MJ, Hales PW, Bollensdorff C, Robson MD et al. Microscopic magnetic resonance imaging reveals high prevalence of third coronary artery in human and rabbit heart. Europace. 2012 Nov 1;14(SUPPL. 5). https://doi.org/10.1093/europace/eus276
Burton, Rebecca A B ; Schneider, Jürgen E. ; Bishop, Martin J. ; Hales, Patrick W. ; Bollensdorff, Christian ; Robson, Matthew D. ; Wong, Kelvin C K ; Morris, John ; Quinn, T. Alexander ; Kohl, Peter. / Microscopic magnetic resonance imaging reveals high prevalence of third coronary artery in human and rabbit heart. In: Europace. 2012 ; Vol. 14, No. SUPPL. 5.
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abstract = "AimThe human coronary tree is commonly assumed to have two roots: the left and right coronary arteries (LCA and RCA, respectively). However, a third coronary artery (TCA) has been observed in humans and animals, usually arising from the right anterior aortic sinus near the RCA. Using high-resolution magnetic resonance imaging, we identified TCA prevalence and characteristics in rabbit and human hearts.Methods and resultsThird coronary artery presence was analysed in hearts from 11 New Zealand white rabbits and 7 human cadavers, using excised tissue that was fixed, gadolinium-treated, and agar-embedded for imaging-based reconstruction. A TCA was identified in all rabbit hearts and six of seven human hearts, originating either from an independent ostium (7 of 11 rabbits, 2 of 7 humans) or an ostium shared with the RCA (4 of 11 rabbits, 4 of 7 humans). Proximal TCA cross-sectional area in rabbits was 15.3 ± 6.0 of RCA area (mean ± SD, based on n 9 rabbit hearts in which reliable measurements could be taken for both vessels), and 26.7 ± 10.1 in humans (n 4). In all-but-one case where a TCA was observed, it originated ventral to the RCA, progressing towards the right ventricular outflow tract. In one rabbit, the TCA originated dorsal to the RCA and progressed towards the Crista terminalis in the right atrium. A fourth vessel, forming a separate aortic Vas vasorum was occasionally seen, originating from the right anterior aortic sinus either from an ostium common with (1 of 11 rabbits, 0 of 7 humans) or independent of (1 of 11 rabbits, 1 of 7 humans) the TCA. Pilot optical mapping experiments showed that TCA occlusion had variable acute effects on rabbit cardiac electrophysiology.ConclusionThird coronary artery presence is common in rabbit and human hearts. Functional effects of disrupted TCA blood supply are ill-investigated, and the rabbit may be a suitable species for such research.",
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AU - Burton, Rebecca A B

AU - Schneider, Jürgen E.

AU - Bishop, Martin J.

AU - Hales, Patrick W.

AU - Bollensdorff, Christian

AU - Robson, Matthew D.

AU - Wong, Kelvin C K

AU - Morris, John

AU - Quinn, T. Alexander

AU - Kohl, Peter

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N2 - AimThe human coronary tree is commonly assumed to have two roots: the left and right coronary arteries (LCA and RCA, respectively). However, a third coronary artery (TCA) has been observed in humans and animals, usually arising from the right anterior aortic sinus near the RCA. Using high-resolution magnetic resonance imaging, we identified TCA prevalence and characteristics in rabbit and human hearts.Methods and resultsThird coronary artery presence was analysed in hearts from 11 New Zealand white rabbits and 7 human cadavers, using excised tissue that was fixed, gadolinium-treated, and agar-embedded for imaging-based reconstruction. A TCA was identified in all rabbit hearts and six of seven human hearts, originating either from an independent ostium (7 of 11 rabbits, 2 of 7 humans) or an ostium shared with the RCA (4 of 11 rabbits, 4 of 7 humans). Proximal TCA cross-sectional area in rabbits was 15.3 ± 6.0 of RCA area (mean ± SD, based on n 9 rabbit hearts in which reliable measurements could be taken for both vessels), and 26.7 ± 10.1 in humans (n 4). In all-but-one case where a TCA was observed, it originated ventral to the RCA, progressing towards the right ventricular outflow tract. In one rabbit, the TCA originated dorsal to the RCA and progressed towards the Crista terminalis in the right atrium. A fourth vessel, forming a separate aortic Vas vasorum was occasionally seen, originating from the right anterior aortic sinus either from an ostium common with (1 of 11 rabbits, 0 of 7 humans) or independent of (1 of 11 rabbits, 1 of 7 humans) the TCA. Pilot optical mapping experiments showed that TCA occlusion had variable acute effects on rabbit cardiac electrophysiology.ConclusionThird coronary artery presence is common in rabbit and human hearts. Functional effects of disrupted TCA blood supply are ill-investigated, and the rabbit may be a suitable species for such research.

AB - AimThe human coronary tree is commonly assumed to have two roots: the left and right coronary arteries (LCA and RCA, respectively). However, a third coronary artery (TCA) has been observed in humans and animals, usually arising from the right anterior aortic sinus near the RCA. Using high-resolution magnetic resonance imaging, we identified TCA prevalence and characteristics in rabbit and human hearts.Methods and resultsThird coronary artery presence was analysed in hearts from 11 New Zealand white rabbits and 7 human cadavers, using excised tissue that was fixed, gadolinium-treated, and agar-embedded for imaging-based reconstruction. A TCA was identified in all rabbit hearts and six of seven human hearts, originating either from an independent ostium (7 of 11 rabbits, 2 of 7 humans) or an ostium shared with the RCA (4 of 11 rabbits, 4 of 7 humans). Proximal TCA cross-sectional area in rabbits was 15.3 ± 6.0 of RCA area (mean ± SD, based on n 9 rabbit hearts in which reliable measurements could be taken for both vessels), and 26.7 ± 10.1 in humans (n 4). In all-but-one case where a TCA was observed, it originated ventral to the RCA, progressing towards the right ventricular outflow tract. In one rabbit, the TCA originated dorsal to the RCA and progressed towards the Crista terminalis in the right atrium. A fourth vessel, forming a separate aortic Vas vasorum was occasionally seen, originating from the right anterior aortic sinus either from an ostium common with (1 of 11 rabbits, 0 of 7 humans) or independent of (1 of 11 rabbits, 1 of 7 humans) the TCA. Pilot optical mapping experiments showed that TCA occlusion had variable acute effects on rabbit cardiac electrophysiology.ConclusionThird coronary artery presence is common in rabbit and human hearts. Functional effects of disrupted TCA blood supply are ill-investigated, and the rabbit may be a suitable species for such research.

KW - Arrhythmia

KW - Conus arteriosus

KW - Coronary tree

KW - Rabbit model

KW - Right ventricular outflow tract

KW - Third coronary artery

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