MicroRNAs: Small RNAs with big effects

Dany Anglicheau, Thangamani Muthukumar, Manikkam Suthanthiran

Research output: Contribution to journalReview article

91 Citations (Scopus)

Abstract

MicroRNAs (miRNAs) are evolutionarily conserved, small (∼20-25 nucleotides), single-stranded molecules that suppress the expression of protein-coding genes by translational repression, messenger RNA degradation, or both. More than 700 miRNAs have been identified in the human genome. Amazingly, a single miRNA can regulate the expression of hundreds of mRNAs or proteins within a cell. The small RNAs are fast emerging as master regulators of innate and adaptive immunity and likely to play a pivotal role in transplantation. The clinical application of RNA sequencing ("next-generation sequencing") should facilitate transcriptome profiling at an unprecedented resolution. We provide an overview of miRNA biology and their hypothesized roles in transplantation.

Original languageEnglish
Pages (from-to)105-112
Number of pages8
JournalTransplantation
Volume90
Issue number2
DOIs
Publication statusPublished - 27 Jul 2010

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Keywords

  • Biomarker
  • Diagnosis
  • Immune Monitoring
  • MicroRNA
  • Transplantation

ASJC Scopus subject areas

  • Transplantation

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