MicroRNAs and Transplantation

Zahraa Khan, Manikkam Suthanthiran, Thangamani Muthukumar

Research output: Contribution to journalArticle

Abstract

miRNAs, ∼20 to 22 nucleotide single-stranded RNA species that play a pivotal role in the regulation of protein-coding genes, are emerging as robust biomarkers for assessing allograft status. Herein, the authors briefly review the biogenesis and function of the miRNAs and provide an overview of the tools to quantify miRNAs in tissues and body fluids. They then review their studies of discovery and validation of alterations in miRNA expression within kidney allografts with or without acute rejection, as well as with or without fibrosis, and summarize published data on miRNA expression patterns in kidney transplant recipients.

Original languageEnglish
JournalClinics in Laboratory Medicine
DOIs
Publication statusAccepted/In press - 1 Jan 2018

Fingerprint

MicroRNAs
Transplantation
Allografts
Kidney
Transplants
Validation Studies
Body fluids
Body Fluids
Biomarkers
Fibrosis
Nucleotides
Genes
RNA
Tissue
Proteins

Keywords

  • Biomarkers
  • Kidney transplantation
  • miRNA
  • Rejection

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Biochemistry, medical

Cite this

MicroRNAs and Transplantation. / Khan, Zahraa; Suthanthiran, Manikkam; Muthukumar, Thangamani.

In: Clinics in Laboratory Medicine, 01.01.2018.

Research output: Contribution to journalArticle

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