Microbiome as an Immunological Modifier

Manoj Kumar, Parul Singh, Selvasankar Murugesan, Marie Vetizou, John McCulloch, Jonathan H. Badger, Giorgio Trinchieri, Souhaila M. Al Khodor

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Humans are living ecosystems composed of human cells and microbes. The microbiome is the collection of microbes (microbiota) and their genes. Recent breakthroughs in the high-throughput sequencing technologies have made it possible for us to understand the composition of the human microbiome. Launched by the National Institutes of Health in USA, the human microbiome project indicated that our bodies harbor a wide array of microbes, specific to each body site with interpersonal and intrapersonal variabilities. Numerous studies have indicated that several factors influence the development of the microbiome including genetics, diet, use of antibiotics, and lifestyle, among others. The microbiome and its mediators are in a continuous cross talk with the host immune system; hence, any imbalance on one side is reflected on the other. Dysbiosis (microbiota imbalance) was shown in many diseases and pathological conditions such as inflammatory bowel disease, celiac disease, multiple sclerosis, rheumatoid arthritis, asthma, diabetes, and cancer. The microbial composition mirrors inflammation variations in certain disease conditions, within various stages of the same disease; hence, it has the potential to be used as a biomarker.

Original languageEnglish
Pages (from-to)595-638
Number of pages44
JournalMethods in molecular biology (Clifton, N.J.)
Volume2055
DOIs
Publication statusPublished - 1 Jan 2020

Fingerprint

Microbiota
Dysbiosis
National Institutes of Health (U.S.)
Celiac Disease
Inflammatory Bowel Diseases
Multiple Sclerosis
Ecosystem
Life Style
Immune System
Rheumatoid Arthritis
Asthma
Biomarkers
Anti-Bacterial Agents
Diet
Inflammation
Technology
Genes
Neoplasms

Keywords

  • Dysbiosis
  • Metagenomics
  • Microbe–immune cell interactions
  • Microbiome
  • Microbiota

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics

Cite this

Microbiome as an Immunological Modifier. / Kumar, Manoj; Singh, Parul; Murugesan, Selvasankar; Vetizou, Marie; McCulloch, John; Badger, Jonathan H.; Trinchieri, Giorgio; Al Khodor, Souhaila M.

In: Methods in molecular biology (Clifton, N.J.), Vol. 2055, 01.01.2020, p. 595-638.

Research output: Contribution to journalArticle

Kumar, M, Singh, P, Murugesan, S, Vetizou, M, McCulloch, J, Badger, JH, Trinchieri, G & Al Khodor, SM 2020, 'Microbiome as an Immunological Modifier', Methods in molecular biology (Clifton, N.J.), vol. 2055, pp. 595-638. https://doi.org/10.1007/978-1-4939-9773-2_27
Kumar, Manoj ; Singh, Parul ; Murugesan, Selvasankar ; Vetizou, Marie ; McCulloch, John ; Badger, Jonathan H. ; Trinchieri, Giorgio ; Al Khodor, Souhaila M. / Microbiome as an Immunological Modifier. In: Methods in molecular biology (Clifton, N.J.). 2020 ; Vol. 2055. pp. 595-638.
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