Micro-RNAs and Next Generation Sequencing: New perspectives in Heart Failure

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

miRNAs are small non-coding RNAs that regulate gene expression. They have significant role in the regulation of cardiovascular function and conditions, such as Heart Failure (HF), as demonstrated by studies of miRNA expression profiling in myocardial tissue. The importance of the use of miRNAs as biomarkers in HF was enhanced when found that they exist extracellularly, with remarkable stability and there are indications that their expression levels reflect the cell response in cardiovascular conditions including Heart Failure. Advances in technology and bioinformatics broaden the field of applications of miRNAs in HF. The introduction of new platforms, such as Next Generation Sequencing, enabled the discovery of novel miRNAs that might be utilized as Heart Failure biomarkers for diagnostic and prognostic purposes and with potential applications in targeted therapeutics.

Original languageEnglish
Pages (from-to)114-119
Number of pages6
JournalClinica Chimica Acta
Volume443
DOIs
Publication statusPublished - 1 Mar 2015

Fingerprint

MicroRNAs
Heart Failure
Biomarkers
Small Untranslated RNA
Bioinformatics
Computational Biology
Gene expression
Tissue
Technology
Gene Expression
Therapeutics

Keywords

  • Heart Failure
  • MiRNA
  • Next Generation Sequencing

ASJC Scopus subject areas

  • Biochemistry
  • Clinical Biochemistry
  • Biochemistry, medical

Cite this

Micro-RNAs and Next Generation Sequencing : New perspectives in Heart Failure. / Chini, Vasiliki P.

In: Clinica Chimica Acta, Vol. 443, 01.03.2015, p. 114-119.

Research output: Contribution to journalArticle

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