MGAT5 and disease severity in progressive multiple sclerosis

Federica Esposito, Jerome Wojcik, Mariaemma Rodegher, Marta Radaelli, Lucia Moiola, Angelo Ghezzi, Ruggero Capra, Paola Brambilla, Melissa Sorosina, Giacomo Giacalone, Vittorio Martinelli, Giancarlo Comi, Hadi Abderrahim, Filippo Martinelli Boneschi

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    5 Citations (Scopus)

    Abstract

    MGAT5 was demonstrated to be associated to multiple sclerosis (MS) severity. We evaluated its role in progressive MS. We studied 11 SNPs mapping to MGAT5 in an Italian cohort of primary progressive or progressive-relapsing patients. The rs1257169G allele is associated with lower disease severity (p-value=0.02). Adding the age of onset as covariate, another SNP, rs539588, is nominally significant. None of the SNPs survived after multiple testing correction. These results, even if suggestive of MGAT5 involvement also in progressive MS severity, require a bigger sample size to confirm and better explore the role of this locus in this rare disease course.

    Original languageEnglish
    Pages (from-to)143-147
    Number of pages5
    JournalJournal of Neuroimmunology
    Volume230
    Issue number1-2
    DOIs
    Publication statusPublished - 1 Jan 2011

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    Keywords

    • Disease progression
    • MGAT5
    • Primary Progressive Multiple Sclerosis
    • Single nucleotide polymorphism

    ASJC Scopus subject areas

    • Immunology and Allergy
    • Immunology
    • Neurology
    • Clinical Neurology

    Cite this

    Esposito, F., Wojcik, J., Rodegher, M., Radaelli, M., Moiola, L., Ghezzi, A., Capra, R., Brambilla, P., Sorosina, M., Giacalone, G., Martinelli, V., Comi, G., Abderrahim, H., & Boneschi, F. M. (2011). MGAT5 and disease severity in progressive multiple sclerosis. Journal of Neuroimmunology, 230(1-2), 143-147. https://doi.org/10.1016/j.jneuroim.2010.10.026