MGAT5 and disease severity in progressive multiple sclerosis

Federica Esposito, Jerome Wojcik, Mariaemma Rodegher, Marta Radaelli, Lucia Moiola, Angelo Ghezzi, Ruggero Capra, Paola Brambilla, Melissa Sorosina, Giacomo Giacalone, Vittorio Martinelli, Giancarlo Comi, Hadi Abderrahim, Filippo Martinelli Boneschi

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

MGAT5 was demonstrated to be associated to multiple sclerosis (MS) severity. We evaluated its role in progressive MS. We studied 11 SNPs mapping to MGAT5 in an Italian cohort of primary progressive or progressive-relapsing patients. The rs1257169G allele is associated with lower disease severity (p-value=0.02). Adding the age of onset as covariate, another SNP, rs539588, is nominally significant. None of the SNPs survived after multiple testing correction. These results, even if suggestive of MGAT5 involvement also in progressive MS severity, require a bigger sample size to confirm and better explore the role of this locus in this rare disease course.

Original languageEnglish
Pages (from-to)143-147
Number of pages5
JournalJournal of Neuroimmunology
Volume230
Issue number1-2
DOIs
Publication statusPublished - 1 Jan 2011
Externally publishedYes

Fingerprint

Multiple Sclerosis
Single Nucleotide Polymorphism
Rare Diseases
Age of Onset
Sample Size
Alleles

Keywords

  • Disease progression
  • MGAT5
  • Primary Progressive Multiple Sclerosis
  • Single nucleotide polymorphism

ASJC Scopus subject areas

  • Immunology
  • Clinical Neurology
  • Immunology and Allergy
  • Neurology

Cite this

Esposito, F., Wojcik, J., Rodegher, M., Radaelli, M., Moiola, L., Ghezzi, A., ... Boneschi, F. M. (2011). MGAT5 and disease severity in progressive multiple sclerosis. Journal of Neuroimmunology, 230(1-2), 143-147. https://doi.org/10.1016/j.jneuroim.2010.10.026

MGAT5 and disease severity in progressive multiple sclerosis. / Esposito, Federica; Wojcik, Jerome; Rodegher, Mariaemma; Radaelli, Marta; Moiola, Lucia; Ghezzi, Angelo; Capra, Ruggero; Brambilla, Paola; Sorosina, Melissa; Giacalone, Giacomo; Martinelli, Vittorio; Comi, Giancarlo; Abderrahim, Hadi; Boneschi, Filippo Martinelli.

In: Journal of Neuroimmunology, Vol. 230, No. 1-2, 01.01.2011, p. 143-147.

Research output: Contribution to journalArticle

Esposito, F, Wojcik, J, Rodegher, M, Radaelli, M, Moiola, L, Ghezzi, A, Capra, R, Brambilla, P, Sorosina, M, Giacalone, G, Martinelli, V, Comi, G, Abderrahim, H & Boneschi, FM 2011, 'MGAT5 and disease severity in progressive multiple sclerosis', Journal of Neuroimmunology, vol. 230, no. 1-2, pp. 143-147. https://doi.org/10.1016/j.jneuroim.2010.10.026
Esposito F, Wojcik J, Rodegher M, Radaelli M, Moiola L, Ghezzi A et al. MGAT5 and disease severity in progressive multiple sclerosis. Journal of Neuroimmunology. 2011 Jan 1;230(1-2):143-147. https://doi.org/10.1016/j.jneuroim.2010.10.026
Esposito, Federica ; Wojcik, Jerome ; Rodegher, Mariaemma ; Radaelli, Marta ; Moiola, Lucia ; Ghezzi, Angelo ; Capra, Ruggero ; Brambilla, Paola ; Sorosina, Melissa ; Giacalone, Giacomo ; Martinelli, Vittorio ; Comi, Giancarlo ; Abderrahim, Hadi ; Boneschi, Filippo Martinelli. / MGAT5 and disease severity in progressive multiple sclerosis. In: Journal of Neuroimmunology. 2011 ; Vol. 230, No. 1-2. pp. 143-147.
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