Methicillin-resistant Staphylococcus aureus producing Panton-Valentine leukocidin as a cause of acute osteomyelitis in children

G. Sdougkos, V. Chini, D. A. Papanastasiou, G. Christodoulou, G. Tagaris, G. Dimitracopoulos, I. Spiliopoulou

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Staphylococcus aureus was identified as the cause of acute childhood osteomyelitis in 19 patients. A single clone of community-acquired methicillin-resistant S. aureus (MRSA) carrying the type IV mecA staphylococcal cassette chromosome and the Panton-Valentine leukocidin (PVL) genes was isolated from five patients. Among the remaining 14 patients, two methicillin-sensitive S. aureus (MSSA) isolates were PVL-positive. The maximal erythrocyte sedimentation rate and C-reactive protein values, and the time required for normalisation, were significantly different in patients with PVL-positive strains (MRSA and MSSA), suggesting that the production of PVL is an important factor that contributes to the course of the disease.

Original languageEnglish
Pages (from-to)651-654
Number of pages4
JournalClinical Microbiology and Infection
Issue number6
Publication statusPublished - Jun 2007
Externally publishedYes



  • Acute osteomyelitis
  • Children
  • Methicillin-resistant Staphylococcus aureus
  • Panton-Valentine leukocidin
  • Staphylococcus aureus

ASJC Scopus subject areas

  • Microbiology (medical)
  • Microbiology

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