Methicillin-resistant Staphylococcus aureus producing Panton-Valentine leukocidin as a cause of acute osteomyelitis in children

G. Sdougkos, V. Chini, D. A. Papanastasiou, G. Christodoulou, G. Tagaris, G. Dimitracopoulos, I. Spiliopoulou

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Staphylococcus aureus was identified as the cause of acute childhood osteomyelitis in 19 patients. A single clone of community-acquired methicillin-resistant S. aureus (MRSA) carrying the type IV mecA staphylococcal cassette chromosome and the Panton-Valentine leukocidin (PVL) genes was isolated from five patients. Among the remaining 14 patients, two methicillin-sensitive S. aureus (MSSA) isolates were PVL-positive. The maximal erythrocyte sedimentation rate and C-reactive protein values, and the time required for normalisation, were significantly different in patients with PVL-positive strains (MRSA and MSSA), suggesting that the production of PVL is an important factor that contributes to the course of the disease.

Original languageEnglish
Pages (from-to)651-654
Number of pages4
JournalClinical Microbiology and Infection
Volume13
Issue number6
DOIs
Publication statusPublished - Jun 2007
Externally publishedYes

Fingerprint

Osteomyelitis
Methicillin-Resistant Staphylococcus aureus
Staphylococcus aureus
Methicillin
Blood Sedimentation
C-Reactive Protein
Clone Cells
Chromosomes
Panton-Valentine leukocidin
Genes

Keywords

  • Acute osteomyelitis
  • Children
  • Methicillin-resistant Staphylococcus aureus
  • Panton-Valentine leukocidin
  • Staphylococcus aureus

ASJC Scopus subject areas

  • Microbiology (medical)
  • Microbiology

Cite this

Methicillin-resistant Staphylococcus aureus producing Panton-Valentine leukocidin as a cause of acute osteomyelitis in children. / Sdougkos, G.; Chini, V.; Papanastasiou, D. A.; Christodoulou, G.; Tagaris, G.; Dimitracopoulos, G.; Spiliopoulou, I.

In: Clinical Microbiology and Infection, Vol. 13, No. 6, 06.2007, p. 651-654.

Research output: Contribution to journalArticle

Sdougkos, G. ; Chini, V. ; Papanastasiou, D. A. ; Christodoulou, G. ; Tagaris, G. ; Dimitracopoulos, G. ; Spiliopoulou, I. / Methicillin-resistant Staphylococcus aureus producing Panton-Valentine leukocidin as a cause of acute osteomyelitis in children. In: Clinical Microbiology and Infection. 2007 ; Vol. 13, No. 6. pp. 651-654.
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