Metal toxicity at the synapse

Presynaptic, postsynaptic, and long-term effects

Sanah Sadiq, Zena Ghazala, Arnab Chowdhury, Dietrich Busselberg

Research output: Contribution to journalReview article

39 Citations (Scopus)

Abstract

Metal neurotoxicity is a global health concern. This paper summarizes the evidence for metal interactions with synaptic transmission and synaptic plasticity. Presynaptically metal ions modulate neurotransmitter release through their interaction with synaptic vesicles, ion channels, and the metabolism of neurotransmitters (NT). Many metals (e.g., Pb 2+, Cd 2+, and Hg +) also interact with intracellular signaling pathways. Postsynaptically, processes associated with the binding of NT to their receptors, activation of channels, and degradation of NT are altered by metals. Zn 2+, Pb 2 2+, Cu 2+, Cd 2+, Ni 2+, Co 2+, Li 2+, Hg +, and methylmercury modulate NMDA, AMPA/kainate, and/or GABA receptors activity. Al 3+, Pb 2+, Cd 2+, and As 2 O 3 also impair synaptic plasticity by targeting molecules such as CaM, PKC, and NOS as well as the transcription machinery involved in the maintenance of synaptic plasticity. The multiple effects of metals might occur simultaneously and are based on the specific metal species, metal concentrations, and the types of neurons involved.

Original languageEnglish
Article number132671
JournalJournal of Toxicology
Volume2012
DOIs
Publication statusPublished - 2012

Fingerprint

Synapses
Toxicity
Metals
Neurotransmitter Agents
Neuronal Plasticity
Plasticity
Kainic Acid Receptors
alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid
GABA Receptors
N-Methylaspartate
Transcription
AMPA Receptors
Synaptic Vesicles
Ion Channels
Metabolism
Neurons
Machinery
Metal ions
Synaptic Transmission
Chemical activation

ASJC Scopus subject areas

  • Toxicology
  • Pharmacology

Cite this

Metal toxicity at the synapse : Presynaptic, postsynaptic, and long-term effects. / Sadiq, Sanah; Ghazala, Zena; Chowdhury, Arnab; Busselberg, Dietrich.

In: Journal of Toxicology, Vol. 2012, 132671, 2012.

Research output: Contribution to journalReview article

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