Metabolomics in cell culture - A strategy to study crucial metabolic pathways in cancer development and the response to treatment

Research output: Contribution to journalReview article

34 Citations (Scopus)

Abstract

Metabolomics is a comprehensive tool for monitoring processes within biological systems. Thus, metabolomics may be widely applied to the determination of diagnostic biomarkers for certain diseases or treatment outcomes. There is significant potential for metabolomics to be implemented in cancer research because cancer may modify metabolic pathways in the whole organism. However, not all biological questions can be answered solely by the examination of small molecule composition in biofluids; in particular, the study of cellular processes or preclinical drug testing requires ex vivo models. The major objective of this review was to summarise the current achievement in the field of metabolomics in cancer cell culture - focusing on the metabolic pathways regulated in different cancer cell lines - and progress that has been made in the area of drug screening and development by the implementation of metabolomics in cell lines.

Original languageEnglish
Pages (from-to)100-109
Number of pages10
JournalArchives of Biochemistry and Biophysics
Volume564
DOIs
Publication statusPublished - 15 Dec 2014
Externally publishedYes

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Metabolomics
Metabolic Networks and Pathways
Cell culture
Cell Culture Techniques
Neoplasms
Cells
Biological Phenomena
Cell Line
Preclinical Drug Evaluations
Process monitoring
Biomarkers
Biological systems
Pharmaceutical Preparations
Screening
Molecules
Testing
Chemical analysis
Research

Keywords

  • Cancer cell lines
  • Cell culture
  • Drug screening
  • Metabolic alterations
  • Metabolomics

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology

Cite this

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