Abstract
Metabolic profiling, or metabolomics, has developed into a mature science in recent years. It has major applications in the study of metabolic disorders. This review addresses issues relevant to the choice of the metabolomics platform, study design and data analysis in diabetes research, and presents recent advances using metabolomics in the identification of markers for altered metabolic pathways, biomarker discovery, challenge studies, metabolic markers of drug efficacy and off-target effects. The role of genetic variance and intermediate metabolic phenotypes and its relevance to diabetes research is also addressed.
| Original language | English |
|---|---|
| Journal | Journal of Endocrinology |
| Volume | 221 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - 2014 |
| Externally published | Yes |
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Keywords
- Diabetes
- Glucose metabolism
- Insulin resistance
- Lipid
- Metabolism
ASJC Scopus subject areas
- Endocrinology, Diabetes and Metabolism
- Endocrinology
Cite this
Metabolic profiling in diabetes. / Suhre, Karsten.
In: Journal of Endocrinology, Vol. 221, No. 3, 2014.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Metabolic profiling in diabetes
AU - Suhre, Karsten
PY - 2014
Y1 - 2014
N2 - Metabolic profiling, or metabolomics, has developed into a mature science in recent years. It has major applications in the study of metabolic disorders. This review addresses issues relevant to the choice of the metabolomics platform, study design and data analysis in diabetes research, and presents recent advances using metabolomics in the identification of markers for altered metabolic pathways, biomarker discovery, challenge studies, metabolic markers of drug efficacy and off-target effects. The role of genetic variance and intermediate metabolic phenotypes and its relevance to diabetes research is also addressed.
AB - Metabolic profiling, or metabolomics, has developed into a mature science in recent years. It has major applications in the study of metabolic disorders. This review addresses issues relevant to the choice of the metabolomics platform, study design and data analysis in diabetes research, and presents recent advances using metabolomics in the identification of markers for altered metabolic pathways, biomarker discovery, challenge studies, metabolic markers of drug efficacy and off-target effects. The role of genetic variance and intermediate metabolic phenotypes and its relevance to diabetes research is also addressed.
KW - Diabetes
KW - Glucose metabolism
KW - Insulin resistance
KW - Lipid
KW - Metabolism
UR - http://www.scopus.com/inward/record.url?scp=84901592466&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84901592466&partnerID=8YFLogxK
U2 - 10.1530/JOE-14-0024
DO - 10.1530/JOE-14-0024
M3 - Review article
C2 - 24868111
AN - SCOPUS:84901592466
VL - 221
JO - Journal of Endocrinology
JF - Journal of Endocrinology
SN - 0022-0795
IS - 3
ER -