Metabolic fingerprints of circulating IGF-1 and the IGF-1/IGFBP-3 Ratio

A multifluid metabolomics study

Henrike Knacke, Maik Pietzner, Kieu Trinh Do, Werner Römisch-Margl, Gabi Kastenmüller, Uwe Völker, Henry Völzke, Jan Krumsiek, Anna Artati, Henri Wallaschofski, Matthias Nauck, Karsten Suhre, Jerzy Adamski, Nele Friedrich

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Objective: IGF-1 is known for its various physiological and severe pathophysiological effects on human metabolism; however, underlying molecular mechanisms still remain unsolved. To reveal possible molecular mechanisms mediating these effects, for the first time, we associated serum IGF-1 levels with multifluid untargeted metabolomics data. Methods: Plasma/urine samples of 995 nondiabetic participants of the Study of Health in Pomerania were characterized by mass spectrometry. Sex-specific linear regression analyses were performed to assess the association of IGF-1 and IGF-1/IGF binding protein 3 ratio with metabolites. Additionally, the predictive ability of the plasma and urine metabolome for IGF-1 was assessed by orthogonal partial least squares analyses. Results and Conclusions: We revealed a multifaceted image of associated metabolites with large sex differences. Confirming previous reports, we detected relations between IGF-1 and steroid hormones or related intermediates. Furthermore, various associated metabolites were previously mentioned regarding IGF-1-associated diseases, eg, betaine and cortisol in cardiovascular disease and metabolic syndrome,lipid disorders,anddiabetes,orhavepreviouslybeenfoundtoassociatewithdifferentiation and proliferation or mitochondrial functionality, eg, phospholipids. bradykinin, fatty acid derivatives, and cortisol, which were inversely associated with IGF-1, might establish a link of IGF-1 with inflammation. For the first time,weshowedanassociationbetweenIGF-1andpipecolate,ametabolite linked to amino acid metabolism. Our study demonstrates that IGF-1 action on metabolism is tractable, even in healthy subjects, and that the findings provide a solid basis for further experimental/clinical investigation, eg, searching for inflammatory or cardiovascular disease- or metabolic syndromeassociated biomarkers and therapeutic targets.

Original languageEnglish
Pages (from-to)4730-4742
Number of pages13
JournalJournal of Clinical Endocrinology and Metabolism
Volume101
Issue number12
DOIs
Publication statusPublished - 1 Dec 2016
Externally publishedYes

Fingerprint

Insulin-Like Growth Factor Binding Protein 3
Metabolomics
Dermatoglyphics
Insulin-Like Growth Factor I
Metabolites
Metabolism
Hydrocortisone
Cardiovascular Diseases
Steroid hormones
Urine
Plasmas
Betaine
Metabolome
Bradykinin
Biomarkers
Least-Squares Analysis
Linear regression
Sex Characteristics
Mass spectrometry
Linear Models

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Endocrinology
  • Clinical Biochemistry
  • Biochemistry, medical

Cite this

Knacke, H., Pietzner, M., Do, K. T., Römisch-Margl, W., Kastenmüller, G., Völker, U., ... Friedrich, N. (2016). Metabolic fingerprints of circulating IGF-1 and the IGF-1/IGFBP-3 Ratio: A multifluid metabolomics study. Journal of Clinical Endocrinology and Metabolism, 101(12), 4730-4742. https://doi.org/10.1210/jc.2016-2588

Metabolic fingerprints of circulating IGF-1 and the IGF-1/IGFBP-3 Ratio : A multifluid metabolomics study. / Knacke, Henrike; Pietzner, Maik; Do, Kieu Trinh; Römisch-Margl, Werner; Kastenmüller, Gabi; Völker, Uwe; Völzke, Henry; Krumsiek, Jan; Artati, Anna; Wallaschofski, Henri; Nauck, Matthias; Suhre, Karsten; Adamski, Jerzy; Friedrich, Nele.

In: Journal of Clinical Endocrinology and Metabolism, Vol. 101, No. 12, 01.12.2016, p. 4730-4742.

Research output: Contribution to journalArticle

Knacke, H, Pietzner, M, Do, KT, Römisch-Margl, W, Kastenmüller, G, Völker, U, Völzke, H, Krumsiek, J, Artati, A, Wallaschofski, H, Nauck, M, Suhre, K, Adamski, J & Friedrich, N 2016, 'Metabolic fingerprints of circulating IGF-1 and the IGF-1/IGFBP-3 Ratio: A multifluid metabolomics study', Journal of Clinical Endocrinology and Metabolism, vol. 101, no. 12, pp. 4730-4742. https://doi.org/10.1210/jc.2016-2588
Knacke, Henrike ; Pietzner, Maik ; Do, Kieu Trinh ; Römisch-Margl, Werner ; Kastenmüller, Gabi ; Völker, Uwe ; Völzke, Henry ; Krumsiek, Jan ; Artati, Anna ; Wallaschofski, Henri ; Nauck, Matthias ; Suhre, Karsten ; Adamski, Jerzy ; Friedrich, Nele. / Metabolic fingerprints of circulating IGF-1 and the IGF-1/IGFBP-3 Ratio : A multifluid metabolomics study. In: Journal of Clinical Endocrinology and Metabolism. 2016 ; Vol. 101, No. 12. pp. 4730-4742.
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AU - Völzke, Henry

AU - Krumsiek, Jan

AU - Artati, Anna

AU - Wallaschofski, Henri

AU - Nauck, Matthias

AU - Suhre, Karsten

AU - Adamski, Jerzy

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