Melanoma-restricted genes

Ena Wang, Monica C. Panelli, Katia Zavaglia, Susanna Mandruzzato, Nan Hu, Phil R. Taylor, Barbara Seliger, Paolo Zanovello, Ralph S. Freedman, Francesco M. Marincola

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

Human metastatic cutaneous melanoma has gained a well deserved reputation for its immune responsiveness. The reason(s) remain(s) unknown. We attempted previously to characterize several variables that may affect the relationship between tumor and host immune cells but, taken one at the time, none yielded a convincing explanation. With explorative purposes, highthroughput technology was applied here to portray transcriptional characteristics unique to metastatic cutaneous melanoma that may or may not be relevant to its immunogenic potential. Several functional signatures could be identified descriptive of immune or other biological functions. In addition, the transcriptional profile of metastatic melanoma was compared with that of primary renal cell cancers (RCC) identifying several genes co-coordinately expressed by the two tumor types. Since RCC is another immune responsive tumor, commonalities between RCC and melanoma may help untangle the enigma of their potential immune responsiveness. This purely descriptive study provides, therefore, a map for the investigation of metastatic melanoma in future clinical trials and at the same time may invite consideration of novel therapeutic targets.

Original languageEnglish
JournalJournal of Translational Medicine
Volume2
DOIs
Publication statusPublished - 15 Oct 2004
Externally publishedYes

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Tumors
Melanoma
Genes
Renal Cell Carcinoma
Neoplasms
Skin
Clinical Trials
Technology
Therapeutics

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Wang, E., Panelli, M. C., Zavaglia, K., Mandruzzato, S., Hu, N., Taylor, P. R., ... Marincola, F. M. (2004). Melanoma-restricted genes. Journal of Translational Medicine, 2. https://doi.org/10.1186/1479-5876-2-34

Melanoma-restricted genes. / Wang, Ena; Panelli, Monica C.; Zavaglia, Katia; Mandruzzato, Susanna; Hu, Nan; Taylor, Phil R.; Seliger, Barbara; Zanovello, Paolo; Freedman, Ralph S.; Marincola, Francesco M.

In: Journal of Translational Medicine, Vol. 2, 15.10.2004.

Research output: Contribution to journalArticle

Wang, E, Panelli, MC, Zavaglia, K, Mandruzzato, S, Hu, N, Taylor, PR, Seliger, B, Zanovello, P, Freedman, RS & Marincola, FM 2004, 'Melanoma-restricted genes', Journal of Translational Medicine, vol. 2. https://doi.org/10.1186/1479-5876-2-34
Wang E, Panelli MC, Zavaglia K, Mandruzzato S, Hu N, Taylor PR et al. Melanoma-restricted genes. Journal of Translational Medicine. 2004 Oct 15;2. https://doi.org/10.1186/1479-5876-2-34
Wang, Ena ; Panelli, Monica C. ; Zavaglia, Katia ; Mandruzzato, Susanna ; Hu, Nan ; Taylor, Phil R. ; Seliger, Barbara ; Zanovello, Paolo ; Freedman, Ralph S. ; Marincola, Francesco M. / Melanoma-restricted genes. In: Journal of Translational Medicine. 2004 ; Vol. 2.
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