Mechanisms and management of acute renal allograft rejection

Research output: Contribution to journalReview article

25 Citations (Scopus)

Abstract

We used RT-PCR for the molecular characterization of human renal graft rejection. The studies showed that intragraft display of mRNA encoding cytotoxic attack molecule granzyme B, and immunoregulatory cytokines IL-10 or IL-2 are correlates of acute rejection, and intrarenal expression of TGF-1 mRNA, of chronic rejection. The current immunosuppressive protocol involves the use of multiple drugs, each directed at a discrete site in the Tcell activation cascade and each with distinct side effects. The immunosuppressants can be classified as inhibitors of: transcription (CsA, tacrolimus); nucleotide synthesis (azathioprine, mycophenolate mofetil, and mizoribine); growth factor signal transduction (sirolimus); and differentiation (DSG). Polyclonal antibodies and monoclonal antibodies directed at cell surface proteins are quite effective as induction therapy or anti-rejection drugs.

Original languageEnglish
Pages (from-to)77-94
Number of pages18
JournalSurgical Clinics of North America
Volume78
Issue number1
DOIs
Publication statusPublished - 1 Jan 1998
Externally publishedYes

Fingerprint

Immunosuppressive Agents
Allografts
Mycophenolic Acid
Kidney
Granzymes
Messenger RNA
Azathioprine
Graft Rejection
Tacrolimus
Sirolimus
Pharmaceutical Preparations
Interleukin-10
Immunosuppression
Interleukin-2
Signal Transduction
Intercellular Signaling Peptides and Proteins
Membrane Proteins
Nucleotides
Monoclonal Antibodies
Cytokines

ASJC Scopus subject areas

  • Surgery

Cite this

Mechanisms and management of acute renal allograft rejection. / Suthanthiran, Manikkam; Strom, T. B.

In: Surgical Clinics of North America, Vol. 78, No. 1, 01.01.1998, p. 77-94.

Research output: Contribution to journalReview article

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