Mechanisms and consequences of central nervous system hypoxia

Meredith Turetz, Ronald Crystal

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Citation (Scopus)

Abstract

The brain has high metabolic demands and depends on a continuous source of oxygenated blood that contains glucose, the exclusive substrate required for central nervous system (CNS) energy metabolism. Oxygen is vital in this process because oxidative phosphorylation is the major contributor of adenosine triphosphate (ATP), the energy source needed to maintain cellular function. Cerebral hypoxia, typically due to respiratory or cardiovascular causes, deprives the brain of the ability to produce a sufficient amount of energy to sustain its high metabolic demands. Continued hypoxia leads to cell injury and death by a variety of neurotoxic cascades that remain to be fully elucidated. Cerebral hypoxia is most commonly due to a combination of both hypoxemia and hypoperfusion. It is unlikely that pure arterial hypoxemia ever causes CNS tissue injury and death because, at very severe levels of hypoxemia, cardiovascular depression and hypotension usually occur. The challenge is to discover if there is a way to intervene in these pathways to prevent the cellular destruction and clinical consequences.

Original languageEnglish
Title of host publicationNeurobiology of Disease
PublisherElsevier Inc.
Pages681-688
Number of pages8
ISBN (Print)9780120885923
DOIs
Publication statusPublished - 1 Dec 2007
Externally publishedYes

Fingerprint

Central Nervous System
Brain Hypoxia
Nervous System Trauma
Nerve Tissue
Oxidative Phosphorylation
Brain
Hypotension
Energy Metabolism
Blood Glucose
Cell Death
Adenosine Triphosphate
Oxygen
Hypoxia
Wounds and Injuries

ASJC Scopus subject areas

  • Dentistry(all)
  • Medicine(all)

Cite this

Mechanisms and consequences of central nervous system hypoxia. / Turetz, Meredith; Crystal, Ronald.

Neurobiology of Disease. Elsevier Inc., 2007. p. 681-688.

Research output: Chapter in Book/Report/Conference proceedingChapter

Turetz, Meredith ; Crystal, Ronald. / Mechanisms and consequences of central nervous system hypoxia. Neurobiology of Disease. Elsevier Inc., 2007. pp. 681-688
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