### Abstract

Interval-force relationship of right and left ventricles of the isolated perfused rat heart was quantified by fitting polynomial, linear and mixed linear-exponential functions to the mechanical restitution (MRC) and post extrasystolic potentiation (PESPC) curves. Ventricular maximum developed pressure (Pmax) and its first derivative (dP/dtmax) were used as indices of contractility. MRCs and PESPCs could be separated into two distinct phases: phase A and phase B of MRCs; phase I and phase II of PESPCs. These phases for the right and left ventricle of the rat heart could be explained on the same model of cellular kinetics of the activator calcium, but showed distinct differences from other species. Right and left ventricle inotropic reserve (CRmax), as quantified from the centre of mass of the phase B of MRCs (from normalized Pmax), was (mean ± SE): 132.4±2.05% and 132.1±1.7% at 1 Hz, which increased significantly (P<0.001) to 181.0±5.8% and 182.3±5.2% at 3.3 Hz, respectively. Linear regression of normalized right ventricle extrasystolic responses on the left ventricle responses gave a high correlation coefficient (typically r^{2}=0.97). Time constants of the fitted mechanical restitution (T(MRC)) and post extraystolic potentiation (T(PESPC)) curves were nearly identical for both the ventricles atthe same priming frequency. Typically at 1 Hz, T(MRC) and T(PESPC) (from normalized dP/dtmax) were (mean±SE): 161.6±10.8 and 159.0±13.2 ms for right ventricle, and 196.1±14.5 and 188.3±10.7 ms for left ventricle, respectively. The results of this study indicate that interval-force relationship of the rat heart, as exemplified by CRmax and time constants of the fitted curves, could provide a usefull index for quantifying and comparing right and left ventricular functions.

Original language | English |
---|---|

Pages (from-to) | 164-172 |

Number of pages | 9 |

Journal | Canadian Journal of Cardiology |

Volume | 8 |

Issue number | 2 |

Publication status | Published - 1992 |

Externally published | Yes |

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### ASJC Scopus subject areas

- Cardiology and Cardiovascular Medicine

### Cite this

**Mechanical restitution and post extrasystolic potentiation of perfused rat heart : Quantitative comparison of normal right and left ventricular responses.** / Mesaeli, Nasrin; Juggi, J. S.

Research output: Contribution to journal › Article

*Canadian Journal of Cardiology*, vol. 8, no. 2, pp. 164-172.

}

TY - JOUR

T1 - Mechanical restitution and post extrasystolic potentiation of perfused rat heart

T2 - Quantitative comparison of normal right and left ventricular responses

AU - Mesaeli, Nasrin

AU - Juggi, J. S.

PY - 1992

Y1 - 1992

N2 - Interval-force relationship of right and left ventricles of the isolated perfused rat heart was quantified by fitting polynomial, linear and mixed linear-exponential functions to the mechanical restitution (MRC) and post extrasystolic potentiation (PESPC) curves. Ventricular maximum developed pressure (Pmax) and its first derivative (dP/dtmax) were used as indices of contractility. MRCs and PESPCs could be separated into two distinct phases: phase A and phase B of MRCs; phase I and phase II of PESPCs. These phases for the right and left ventricle of the rat heart could be explained on the same model of cellular kinetics of the activator calcium, but showed distinct differences from other species. Right and left ventricle inotropic reserve (CRmax), as quantified from the centre of mass of the phase B of MRCs (from normalized Pmax), was (mean ± SE): 132.4±2.05% and 132.1±1.7% at 1 Hz, which increased significantly (P<0.001) to 181.0±5.8% and 182.3±5.2% at 3.3 Hz, respectively. Linear regression of normalized right ventricle extrasystolic responses on the left ventricle responses gave a high correlation coefficient (typically r2=0.97). Time constants of the fitted mechanical restitution (T(MRC)) and post extraystolic potentiation (T(PESPC)) curves were nearly identical for both the ventricles atthe same priming frequency. Typically at 1 Hz, T(MRC) and T(PESPC) (from normalized dP/dtmax) were (mean±SE): 161.6±10.8 and 159.0±13.2 ms for right ventricle, and 196.1±14.5 and 188.3±10.7 ms for left ventricle, respectively. The results of this study indicate that interval-force relationship of the rat heart, as exemplified by CRmax and time constants of the fitted curves, could provide a usefull index for quantifying and comparing right and left ventricular functions.

AB - Interval-force relationship of right and left ventricles of the isolated perfused rat heart was quantified by fitting polynomial, linear and mixed linear-exponential functions to the mechanical restitution (MRC) and post extrasystolic potentiation (PESPC) curves. Ventricular maximum developed pressure (Pmax) and its first derivative (dP/dtmax) were used as indices of contractility. MRCs and PESPCs could be separated into two distinct phases: phase A and phase B of MRCs; phase I and phase II of PESPCs. These phases for the right and left ventricle of the rat heart could be explained on the same model of cellular kinetics of the activator calcium, but showed distinct differences from other species. Right and left ventricle inotropic reserve (CRmax), as quantified from the centre of mass of the phase B of MRCs (from normalized Pmax), was (mean ± SE): 132.4±2.05% and 132.1±1.7% at 1 Hz, which increased significantly (P<0.001) to 181.0±5.8% and 182.3±5.2% at 3.3 Hz, respectively. Linear regression of normalized right ventricle extrasystolic responses on the left ventricle responses gave a high correlation coefficient (typically r2=0.97). Time constants of the fitted mechanical restitution (T(MRC)) and post extraystolic potentiation (T(PESPC)) curves were nearly identical for both the ventricles atthe same priming frequency. Typically at 1 Hz, T(MRC) and T(PESPC) (from normalized dP/dtmax) were (mean±SE): 161.6±10.8 and 159.0±13.2 ms for right ventricle, and 196.1±14.5 and 188.3±10.7 ms for left ventricle, respectively. The results of this study indicate that interval-force relationship of the rat heart, as exemplified by CRmax and time constants of the fitted curves, could provide a usefull index for quantifying and comparing right and left ventricular functions.

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M3 - Article

C2 - 1373104

AN - SCOPUS:0026690592

VL - 8

SP - 164

EP - 172

JO - Canadian Journal of Cardiology

JF - Canadian Journal of Cardiology

SN - 0828-282X

IS - 2

ER -