Measuring the public-health impact of candidate HIV vaccines as part of the licensing process

Marie Claude Boily, Laith Aburaddad, Kamal Desai, Benoit Masse, Steve Self, Roy Anderson

Research output: Contribution to journalArticle

16 Citations (Scopus)


The full impact of vaccines against infectious diseases is manifest at both the individual and the community levels. We argue that evaluating the community-level impact of HIV vaccine candidates should be an integral part of the licensing process. We describe a framework for the public-health evaluation of an HIV vaccine, which is based on the interactive use of mathematical models and community randomised clinical trials (C-RCTs) following completion of individual-based clinical trials (I-RCTs). Mathematical models of HIV vaccine can be used to take public-health considerations into account during the licensing process and can also help to select promising vaccine candidates for testing in C-RCTs. We also describe community and individual-based measures useful for defining public-health criteria necessary to guide the licensing process. To move forward, it is crucial to reach a consensus on what should constitute adequate public-health criteria. At the very least, a suitable vaccine would provide some individual benefit to vaccinees and not be detrimental to the population at large. In future I-RCTs and C-RCTs, quantifying each protective vaccine characteristic (eg, reductions in susceptibility or viral load) is important if regulators are to evaluate adequately the potential community-level impact of the vaccine across different settings, populations, and conditions of use.

Original languageEnglish
Pages (from-to)200-207
Number of pages8
JournalThe Lancet Infectious Diseases
Issue number3
Publication statusPublished - Mar 2008
Externally publishedYes


ASJC Scopus subject areas

  • Infectious Diseases

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