Measurement of intrinsic properties of amyloid fibrils by the peak force QNM method

Jozef Adamcik, Cecile Lara, Ivan Usov, Jae Sun Jeong, Francesco S. Ruggeri, Giovanni Dietler, Hilal A. Lashuel, Ian W. Hamley, Raffaele Mezzenga

Research output: Contribution to journalArticle

104 Citations (Scopus)

Abstract

We report the investigation of the mechanical properties of different types of amyloid fibrils by the peak force quantitative nanomechanical (PF-QNM) technique. We demonstrate that this technique correctly measures the Young's modulus independent of the polymorphic state and the cross-sectional structural details of the fibrils, and we show that values for amyloid fibrils assembled from heptapeptides, α-synuclein, Aβ(1-42), insulin, β-lactoglobulin, lysozyme, ovalbumin, Tau protein and bovine serum albumin all fall in the range of 2-4 GPa. This journal is

Original languageEnglish
Pages (from-to)4426-4429
Number of pages4
JournalNanoscale
Volume4
Issue number15
DOIs
Publication statusPublished - 7 Aug 2012
Externally publishedYes

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Amyloid
Synucleins
tau Proteins
Lactoglobulins
Insulin
Ovalbumin
Muramidase
Bovine Serum Albumin
Enzymes
Elastic moduli
Proteins
Mechanical properties

ASJC Scopus subject areas

  • Materials Science(all)

Cite this

Adamcik, J., Lara, C., Usov, I., Jeong, J. S., Ruggeri, F. S., Dietler, G., ... Mezzenga, R. (2012). Measurement of intrinsic properties of amyloid fibrils by the peak force QNM method. Nanoscale, 4(15), 4426-4429. https://doi.org/10.1039/c2nr30768e

Measurement of intrinsic properties of amyloid fibrils by the peak force QNM method. / Adamcik, Jozef; Lara, Cecile; Usov, Ivan; Jeong, Jae Sun; Ruggeri, Francesco S.; Dietler, Giovanni; Lashuel, Hilal A.; Hamley, Ian W.; Mezzenga, Raffaele.

In: Nanoscale, Vol. 4, No. 15, 07.08.2012, p. 4426-4429.

Research output: Contribution to journalArticle

Adamcik, J, Lara, C, Usov, I, Jeong, JS, Ruggeri, FS, Dietler, G, Lashuel, HA, Hamley, IW & Mezzenga, R 2012, 'Measurement of intrinsic properties of amyloid fibrils by the peak force QNM method', Nanoscale, vol. 4, no. 15, pp. 4426-4429. https://doi.org/10.1039/c2nr30768e
Adamcik J, Lara C, Usov I, Jeong JS, Ruggeri FS, Dietler G et al. Measurement of intrinsic properties of amyloid fibrils by the peak force QNM method. Nanoscale. 2012 Aug 7;4(15):4426-4429. https://doi.org/10.1039/c2nr30768e
Adamcik, Jozef ; Lara, Cecile ; Usov, Ivan ; Jeong, Jae Sun ; Ruggeri, Francesco S. ; Dietler, Giovanni ; Lashuel, Hilal A. ; Hamley, Ian W. ; Mezzenga, Raffaele. / Measurement of intrinsic properties of amyloid fibrils by the peak force QNM method. In: Nanoscale. 2012 ; Vol. 4, No. 15. pp. 4426-4429.
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