Measurement of intrinsic properties of amyloid fibrils by the peak force QNM method

Jozef Adamcik, Cecile Lara, Ivan Usov, Jae Sun Jeong, Francesco S. Ruggeri, Giovanni Dietler, Hilal A. Lashuel, Ian W. Hamley, Raffaele Mezzenga

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Abstract

We report the investigation of the mechanical properties of different types of amyloid fibrils by the peak force quantitative nanomechanical (PF-QNM) technique. We demonstrate that this technique correctly measures the Young's modulus independent of the polymorphic state and the cross-sectional structural details of the fibrils, and we show that values for amyloid fibrils assembled from heptapeptides, α-synuclein, Aβ(1-42), insulin, β-lactoglobulin, lysozyme, ovalbumin, Tau protein and bovine serum albumin all fall in the range of 2-4 GPa.

Original languageEnglish
Pages (from-to)4426-4429
Number of pages4
JournalNanoscale
Volume4
Issue number15
DOIs
Publication statusPublished - 7 Aug 2012

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ASJC Scopus subject areas

  • Materials Science(all)

Cite this

Adamcik, J., Lara, C., Usov, I., Jeong, J. S., Ruggeri, F. S., Dietler, G., Lashuel, H. A., Hamley, I. W., & Mezzenga, R. (2012). Measurement of intrinsic properties of amyloid fibrils by the peak force QNM method. Nanoscale, 4(15), 4426-4429. https://doi.org/10.1039/c2nr30768e