Measurement of DTI metrics in hemorrhagic brain lesions

Possible implication in MRI interpretation

Mohammad Haris, Rakesh K. Gupta, Nuzhat Husain, Khader M. Hasan, Mazhar Husain, Ponnada A. Narayana

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Purpose: To understand the biological basis of possible mechanisms responsible for increased fractional anisotropy (FA) in different stages of hemorrhage and hemorrhagic brain lesions. Materials and Methods: A total of 19 patients with cerebral hemorrhage (CH), five patients with hemorrhagic infarct (HI), and nine patients with hemorrhagic brain tumor (HBT) were prospectively evaluated with diffusion tensor imaging (DTI) and the FA and mean diffusivity (MD) was quantified. Ex vivo DTI of blood clot and histology of the blood clot and HBT were performed to interpret the temporal changes in the DTI metrics. Results: High FA (>0.20) with low MD in the acute and early subacute stage and low FA (<0.20) with increased MD in the late subacute and chronic stage of CH and HI were observed. HBT showed high FA with low MD at all stages. In CH and HI, a significant reduction in FA (P < 0.001) with increased MD (P < 0.001) was seen in the late subacute and chronic stages compared to the acute and early subacute stages, normal white matter (NWM), and HBT. In HBT, there was no significant statistical difference in the FA values between different stages. Histology of HBT and ex vivo blood clot showed structural organization of intact red blood cells (RBCs) with fibrin mesh where the FA values were high compared to normal tissue region that is devoid of blood. Conclusion: Intact RBCs entangled within fibrin mesh appear to be responsible for high FA in hemorrhagic brain lesions.

Original languageEnglish
Pages (from-to)1259-1268
Number of pages10
JournalJournal of Magnetic Resonance Imaging
Volume24
Issue number6
DOIs
Publication statusPublished - Dec 2006
Externally publishedYes

Fingerprint

Diffusion Tensor Imaging
Anisotropy
Brain Neoplasms
Brain
Cerebral Hemorrhage
Thrombosis
Fibrin
Histology
Erythrocytes
Intracranial Hemorrhages

Keywords

  • Brain
  • Cerebral hemorrhage
  • Diffusion tensor imaging
  • Hemorrhagic brain tumor
  • MRI
  • Red blood cells

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Measurement of DTI metrics in hemorrhagic brain lesions : Possible implication in MRI interpretation. / Haris, Mohammad; Gupta, Rakesh K.; Husain, Nuzhat; Hasan, Khader M.; Husain, Mazhar; Narayana, Ponnada A.

In: Journal of Magnetic Resonance Imaging, Vol. 24, No. 6, 12.2006, p. 1259-1268.

Research output: Contribution to journalArticle

Haris, Mohammad ; Gupta, Rakesh K. ; Husain, Nuzhat ; Hasan, Khader M. ; Husain, Mazhar ; Narayana, Ponnada A. / Measurement of DTI metrics in hemorrhagic brain lesions : Possible implication in MRI interpretation. In: Journal of Magnetic Resonance Imaging. 2006 ; Vol. 24, No. 6. pp. 1259-1268.
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abstract = "Purpose: To understand the biological basis of possible mechanisms responsible for increased fractional anisotropy (FA) in different stages of hemorrhage and hemorrhagic brain lesions. Materials and Methods: A total of 19 patients with cerebral hemorrhage (CH), five patients with hemorrhagic infarct (HI), and nine patients with hemorrhagic brain tumor (HBT) were prospectively evaluated with diffusion tensor imaging (DTI) and the FA and mean diffusivity (MD) was quantified. Ex vivo DTI of blood clot and histology of the blood clot and HBT were performed to interpret the temporal changes in the DTI metrics. Results: High FA (>0.20) with low MD in the acute and early subacute stage and low FA (<0.20) with increased MD in the late subacute and chronic stage of CH and HI were observed. HBT showed high FA with low MD at all stages. In CH and HI, a significant reduction in FA (P < 0.001) with increased MD (P < 0.001) was seen in the late subacute and chronic stages compared to the acute and early subacute stages, normal white matter (NWM), and HBT. In HBT, there was no significant statistical difference in the FA values between different stages. Histology of HBT and ex vivo blood clot showed structural organization of intact red blood cells (RBCs) with fibrin mesh where the FA values were high compared to normal tissue region that is devoid of blood. Conclusion: Intact RBCs entangled within fibrin mesh appear to be responsible for high FA in hemorrhagic brain lesions.",
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