Maternal-fetal immunity

Presence of specific cellular hyporesponsiveness and humoral suppressor activity in normal pregnancy and their absence in preeclampsia

P. A. Taufield, Manikkam Suthanthiran, K. Ales, M. Druzin, L. M. Resnick, J. H. Laragh, K. H. Stenzel, A. L. Rubin

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

The hypothesis that aberrant maternal-fetal immunity might lead to the development of preeclampsia was examined using mixed lymphocyte culture reactions (MLC) as an in vitro analogue of maternal-fetal immunity. Maternal lymphocytes and serum from five normal pregnant women differed significantly from lymphocytes and serum from five preeclamptics. Maternal cells from normal pregnancy responded appropriately to unrelated control cells, but demonstrated selective hyporesponsiveness to fetal cells in the MLC. Serum from normal pregnancy suppressed MLCs when maternal cells were responder cells (RC) and maternal cells or fetal cells were stimulator cells (SC), and did not inhibit MLCs where maternal cells were RC and control cells were SC. Maternal lymphocytes and serum from preeclamptics did not demonstrate cellular hyporesponsiveness or humoral suppressor activity. Our findings support the notion that specific cellular hyporesponsiveness and humoral suppressor activity is responsible for normal pregnancy; absence of such adaptive immunity might lead to the development of preclampsia.

Original languageEnglish
Pages (from-to)123-131
Number of pages9
JournalHypertension in Pregnancy
VolumeB2
Issue number1
DOIs
Publication statusPublished - 1 Jan 1983
Externally publishedYes

Fingerprint

Pre-Eclampsia
Immunity
Mothers
Pregnancy
Mixed Lymphocyte Culture Test
Lymphocytes
Serum
Adaptive Immunity
Pregnant Women

ASJC Scopus subject areas

  • Internal Medicine
  • Obstetrics and Gynaecology

Cite this

Maternal-fetal immunity : Presence of specific cellular hyporesponsiveness and humoral suppressor activity in normal pregnancy and their absence in preeclampsia. / Taufield, P. A.; Suthanthiran, Manikkam; Ales, K.; Druzin, M.; Resnick, L. M.; Laragh, J. H.; Stenzel, K. H.; Rubin, A. L.

In: Hypertension in Pregnancy, Vol. B2, No. 1, 01.01.1983, p. 123-131.

Research output: Contribution to journalArticle

Taufield, P. A. ; Suthanthiran, Manikkam ; Ales, K. ; Druzin, M. ; Resnick, L. M. ; Laragh, J. H. ; Stenzel, K. H. ; Rubin, A. L. / Maternal-fetal immunity : Presence of specific cellular hyporesponsiveness and humoral suppressor activity in normal pregnancy and their absence in preeclampsia. In: Hypertension in Pregnancy. 1983 ; Vol. B2, No. 1. pp. 123-131.
@article{b89ebb29352e4ebfbb352714f44fc88b,
title = "Maternal-fetal immunity: Presence of specific cellular hyporesponsiveness and humoral suppressor activity in normal pregnancy and their absence in preeclampsia",
abstract = "The hypothesis that aberrant maternal-fetal immunity might lead to the development of preeclampsia was examined using mixed lymphocyte culture reactions (MLC) as an in vitro analogue of maternal-fetal immunity. Maternal lymphocytes and serum from five normal pregnant women differed significantly from lymphocytes and serum from five preeclamptics. Maternal cells from normal pregnancy responded appropriately to unrelated control cells, but demonstrated selective hyporesponsiveness to fetal cells in the MLC. Serum from normal pregnancy suppressed MLCs when maternal cells were responder cells (RC) and maternal cells or fetal cells were stimulator cells (SC), and did not inhibit MLCs where maternal cells were RC and control cells were SC. Maternal lymphocytes and serum from preeclamptics did not demonstrate cellular hyporesponsiveness or humoral suppressor activity. Our findings support the notion that specific cellular hyporesponsiveness and humoral suppressor activity is responsible for normal pregnancy; absence of such adaptive immunity might lead to the development of preclampsia.",
author = "Taufield, {P. A.} and Manikkam Suthanthiran and K. Ales and M. Druzin and Resnick, {L. M.} and Laragh, {J. H.} and Stenzel, {K. H.} and Rubin, {A. L.}",
year = "1983",
month = "1",
day = "1",
doi = "10.3109/10641958309023465",
language = "English",
volume = "B2",
pages = "123--131",
journal = "Hypertension in Pregnancy",
issn = "1064-1955",
publisher = "Informa Healthcare",
number = "1",

}

TY - JOUR

T1 - Maternal-fetal immunity

T2 - Presence of specific cellular hyporesponsiveness and humoral suppressor activity in normal pregnancy and their absence in preeclampsia

AU - Taufield, P. A.

AU - Suthanthiran, Manikkam

AU - Ales, K.

AU - Druzin, M.

AU - Resnick, L. M.

AU - Laragh, J. H.

AU - Stenzel, K. H.

AU - Rubin, A. L.

PY - 1983/1/1

Y1 - 1983/1/1

N2 - The hypothesis that aberrant maternal-fetal immunity might lead to the development of preeclampsia was examined using mixed lymphocyte culture reactions (MLC) as an in vitro analogue of maternal-fetal immunity. Maternal lymphocytes and serum from five normal pregnant women differed significantly from lymphocytes and serum from five preeclamptics. Maternal cells from normal pregnancy responded appropriately to unrelated control cells, but demonstrated selective hyporesponsiveness to fetal cells in the MLC. Serum from normal pregnancy suppressed MLCs when maternal cells were responder cells (RC) and maternal cells or fetal cells were stimulator cells (SC), and did not inhibit MLCs where maternal cells were RC and control cells were SC. Maternal lymphocytes and serum from preeclamptics did not demonstrate cellular hyporesponsiveness or humoral suppressor activity. Our findings support the notion that specific cellular hyporesponsiveness and humoral suppressor activity is responsible for normal pregnancy; absence of such adaptive immunity might lead to the development of preclampsia.

AB - The hypothesis that aberrant maternal-fetal immunity might lead to the development of preeclampsia was examined using mixed lymphocyte culture reactions (MLC) as an in vitro analogue of maternal-fetal immunity. Maternal lymphocytes and serum from five normal pregnant women differed significantly from lymphocytes and serum from five preeclamptics. Maternal cells from normal pregnancy responded appropriately to unrelated control cells, but demonstrated selective hyporesponsiveness to fetal cells in the MLC. Serum from normal pregnancy suppressed MLCs when maternal cells were responder cells (RC) and maternal cells or fetal cells were stimulator cells (SC), and did not inhibit MLCs where maternal cells were RC and control cells were SC. Maternal lymphocytes and serum from preeclamptics did not demonstrate cellular hyporesponsiveness or humoral suppressor activity. Our findings support the notion that specific cellular hyporesponsiveness and humoral suppressor activity is responsible for normal pregnancy; absence of such adaptive immunity might lead to the development of preclampsia.

UR - http://www.scopus.com/inward/record.url?scp=0021012384&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0021012384&partnerID=8YFLogxK

U2 - 10.3109/10641958309023465

DO - 10.3109/10641958309023465

M3 - Article

VL - B2

SP - 123

EP - 131

JO - Hypertension in Pregnancy

JF - Hypertension in Pregnancy

SN - 1064-1955

IS - 1

ER -