Maternal C-reactive protein levels in pregnancy are associated with wheezing and lower respiratory tract infections in the offspring

Eva Morales, Stefano Guerra, Raquel Garca-Esteban, Monica Guxens, Mar Alvarez-Pedrerol, Mariona Bustamante, Xavier P. Estivill, Josep Maria Ant, Jordi Sunyer

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Objective We assessed whether maternal C-reactive protein (CRP) levels during pregnancy and CRP gene variations are associated with wheezing and lower respiratory tract infections (LRTIs) in offspring. Study Design Information on wheezing and LRTIs in the offspring at 6 and 14 months of age, and maternal CRP levels and genotype was obtained from a population-based birth cohort. Results A total of 63 children (12.5%) experienced recurrent wheezing and 61 (12.4%) a recurrent diagnosis of LRTIs. Children in the highest tertile of maternal CRP levels had a higher risk of experiencing recurrent wheezing (adjusted odds ratio, 2.87; 95% confidence interval, 1.236.71) and being diagnosed with recurrent LRTIs (odds ratio, 2.37; 95% confidence interval, 1.015.55), as compared with children in the lowest tertile. The rs1205 polymorphism influenced maternal serum CRP levels but not the risk of the offspring outcomes. Conclusion Higher CRP levels in pregnancy are associated with wheezing and LRTIs in offspring. However, genetic variation in CRP influencing maternal levels is not related to these phenotypes.

Original languageEnglish
JournalAmerican Journal of Obstetrics and Gynecology
Volume204
Issue number2
DOIs
Publication statusPublished - Feb 2011
Externally publishedYes

Fingerprint

Respiratory Sounds
Respiratory Tract Infections
C-Reactive Protein
Mothers
Pregnancy
Odds Ratio
Confidence Intervals
Maternal Age
Blood Proteins
Genotype
Parturition
Phenotype
Population
Genes

Keywords

  • C-reactive protein
  • children
  • pregnancy
  • respiratory infections
  • wheezing

ASJC Scopus subject areas

  • Obstetrics and Gynaecology

Cite this

Maternal C-reactive protein levels in pregnancy are associated with wheezing and lower respiratory tract infections in the offspring. / Morales, Eva; Guerra, Stefano; Garca-Esteban, Raquel; Guxens, Monica; Alvarez-Pedrerol, Mar; Bustamante, Mariona; Estivill, Xavier P.; Ant, Josep Maria; Sunyer, Jordi.

In: American Journal of Obstetrics and Gynecology, Vol. 204, No. 2, 02.2011.

Research output: Contribution to journalArticle

Morales, Eva ; Guerra, Stefano ; Garca-Esteban, Raquel ; Guxens, Monica ; Alvarez-Pedrerol, Mar ; Bustamante, Mariona ; Estivill, Xavier P. ; Ant, Josep Maria ; Sunyer, Jordi. / Maternal C-reactive protein levels in pregnancy are associated with wheezing and lower respiratory tract infections in the offspring. In: American Journal of Obstetrics and Gynecology. 2011 ; Vol. 204, No. 2.
@article{1d9d8451a35d495491d7e89d761d0822,
title = "Maternal C-reactive protein levels in pregnancy are associated with wheezing and lower respiratory tract infections in the offspring",
abstract = "Objective We assessed whether maternal C-reactive protein (CRP) levels during pregnancy and CRP gene variations are associated with wheezing and lower respiratory tract infections (LRTIs) in offspring. Study Design Information on wheezing and LRTIs in the offspring at 6 and 14 months of age, and maternal CRP levels and genotype was obtained from a population-based birth cohort. Results A total of 63 children (12.5{\%}) experienced recurrent wheezing and 61 (12.4{\%}) a recurrent diagnosis of LRTIs. Children in the highest tertile of maternal CRP levels had a higher risk of experiencing recurrent wheezing (adjusted odds ratio, 2.87; 95{\%} confidence interval, 1.236.71) and being diagnosed with recurrent LRTIs (odds ratio, 2.37; 95{\%} confidence interval, 1.015.55), as compared with children in the lowest tertile. The rs1205 polymorphism influenced maternal serum CRP levels but not the risk of the offspring outcomes. Conclusion Higher CRP levels in pregnancy are associated with wheezing and LRTIs in offspring. However, genetic variation in CRP influencing maternal levels is not related to these phenotypes.",
keywords = "C-reactive protein, children, pregnancy, respiratory infections, wheezing",
author = "Eva Morales and Stefano Guerra and Raquel Garca-Esteban and Monica Guxens and Mar Alvarez-Pedrerol and Mariona Bustamante and Estivill, {Xavier P.} and Ant, {Josep Maria} and Jordi Sunyer",
year = "2011",
month = "2",
doi = "10.1016/j.ajog.2010.08.056",
language = "English",
volume = "204",
journal = "American Journal of Obstetrics and Gynecology",
issn = "0002-9378",
publisher = "Mosby Inc.",
number = "2",

}

TY - JOUR

T1 - Maternal C-reactive protein levels in pregnancy are associated with wheezing and lower respiratory tract infections in the offspring

AU - Morales, Eva

AU - Guerra, Stefano

AU - Garca-Esteban, Raquel

AU - Guxens, Monica

AU - Alvarez-Pedrerol, Mar

AU - Bustamante, Mariona

AU - Estivill, Xavier P.

AU - Ant, Josep Maria

AU - Sunyer, Jordi

PY - 2011/2

Y1 - 2011/2

N2 - Objective We assessed whether maternal C-reactive protein (CRP) levels during pregnancy and CRP gene variations are associated with wheezing and lower respiratory tract infections (LRTIs) in offspring. Study Design Information on wheezing and LRTIs in the offspring at 6 and 14 months of age, and maternal CRP levels and genotype was obtained from a population-based birth cohort. Results A total of 63 children (12.5%) experienced recurrent wheezing and 61 (12.4%) a recurrent diagnosis of LRTIs. Children in the highest tertile of maternal CRP levels had a higher risk of experiencing recurrent wheezing (adjusted odds ratio, 2.87; 95% confidence interval, 1.236.71) and being diagnosed with recurrent LRTIs (odds ratio, 2.37; 95% confidence interval, 1.015.55), as compared with children in the lowest tertile. The rs1205 polymorphism influenced maternal serum CRP levels but not the risk of the offspring outcomes. Conclusion Higher CRP levels in pregnancy are associated with wheezing and LRTIs in offspring. However, genetic variation in CRP influencing maternal levels is not related to these phenotypes.

AB - Objective We assessed whether maternal C-reactive protein (CRP) levels during pregnancy and CRP gene variations are associated with wheezing and lower respiratory tract infections (LRTIs) in offspring. Study Design Information on wheezing and LRTIs in the offspring at 6 and 14 months of age, and maternal CRP levels and genotype was obtained from a population-based birth cohort. Results A total of 63 children (12.5%) experienced recurrent wheezing and 61 (12.4%) a recurrent diagnosis of LRTIs. Children in the highest tertile of maternal CRP levels had a higher risk of experiencing recurrent wheezing (adjusted odds ratio, 2.87; 95% confidence interval, 1.236.71) and being diagnosed with recurrent LRTIs (odds ratio, 2.37; 95% confidence interval, 1.015.55), as compared with children in the lowest tertile. The rs1205 polymorphism influenced maternal serum CRP levels but not the risk of the offspring outcomes. Conclusion Higher CRP levels in pregnancy are associated with wheezing and LRTIs in offspring. However, genetic variation in CRP influencing maternal levels is not related to these phenotypes.

KW - C-reactive protein

KW - children

KW - pregnancy

KW - respiratory infections

KW - wheezing

UR - http://www.scopus.com/inward/record.url?scp=79551499416&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79551499416&partnerID=8YFLogxK

U2 - 10.1016/j.ajog.2010.08.056

DO - 10.1016/j.ajog.2010.08.056

M3 - Article

VL - 204

JO - American Journal of Obstetrics and Gynecology

JF - American Journal of Obstetrics and Gynecology

SN - 0002-9378

IS - 2

ER -