Matched-related allogeneic stem cell transplantation in Saudi patients with Fanconi anemia

10 year's experience

M. Ayas, A. Al-Jefri, A. Al-Seraihi, Naser Elkum, M. Al-Mahr, H. El-Solh

Research output: Contribution to journalReview article

17 Citations (Scopus)

Abstract

Allogeneic SCT is curative for bone marrow failure in Fanconi anemia (FA) patients but the optimal conditioning regimen is undetermined. We report here our experience with 56 FA patients who underwent allogeneic matched related SCT. The conditioning regimen varied according to time of SCT and disease status at SCT; 22 patients (group A) received Cy 20 mg/kg, thoraco-abdominal radiation and antithymocyte globulins (ATG); and 34 patients (group B) received Cy 60 mg/kg and ATG. Median time to engraftment was similar (14 days) in both groups. Hemorrhagic cystitis was significantly more common in group B. Overall survival and event-free survival of all patients were 85 and 78.3% respectively. For groups A and B respectively, overall survival was 72.5 and 96.9% (P = 0.013); and event-free survival was 72.5 and 82.3% (P = 0.3). The use of the nonradiation Cy/ATG regimen in matched related SCT for FA patients offers better overall and event-free survival.

Original languageEnglish
JournalBone Marrow Transplantation
Volume42
Issue numberSUPPL.1
DOIs
Publication statusPublished - 2008
Externally publishedYes

Fingerprint

Fanconi Anemia
Stem Cell Transplantation
Antilymphocyte Serum
Disease-Free Survival
Cystitis
Survival
Bone Marrow
Radiation

ASJC Scopus subject areas

  • Hematology
  • Transplantation

Cite this

Matched-related allogeneic stem cell transplantation in Saudi patients with Fanconi anemia : 10 year's experience. / Ayas, M.; Al-Jefri, A.; Al-Seraihi, A.; Elkum, Naser; Al-Mahr, M.; El-Solh, H.

In: Bone Marrow Transplantation, Vol. 42, No. SUPPL.1, 2008.

Research output: Contribution to journalReview article

Ayas, M. ; Al-Jefri, A. ; Al-Seraihi, A. ; Elkum, Naser ; Al-Mahr, M. ; El-Solh, H. / Matched-related allogeneic stem cell transplantation in Saudi patients with Fanconi anemia : 10 year's experience. In: Bone Marrow Transplantation. 2008 ; Vol. 42, No. SUPPL.1.
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AU - Al-Mahr, M.

AU - El-Solh, H.

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