Mapping of the human Zn-a2-glycoprotein gene (AZGP1) to chromosome 7q22 by in situ hybridization

A. M. Pendás, T. Matilla, J. A. Uría, J. P. Freije, A. Fueyo, Xavier P. Estivill, Carlos López-Otín

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

The gene coding for Zn-α2-glycoprotein (AZGPI), a human protein with a high degree of similarity to class I major histocompatibility complex (MHC) antigens, was mapped by fluorescent in situ hybridization to chromosome 7q22. a common breakpoint in myelodysplastic syndromes. Since classical MHC genes map on chromosome 6, this assignment indicates that besides duplication of the putative common ancestor gene, transposition events to different chromosomes have also been involved in the evolutionary diversification of this gene family.

Original languageEnglish
Pages (from-to)263-266
Number of pages4
JournalCytogenetic and Genome Research
Volume66
Issue number4
DOIs
Publication statusPublished - 1994
Externally publishedYes

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In Situ Hybridization
Glycoproteins
Chromosomes
Major Histocompatibility Complex
Genes
Histocompatibility Antigens Class I
Chromosomes, Human, Pair 6
Myelodysplastic Syndromes
Fluorescence In Situ Hybridization
Proteins

ASJC Scopus subject areas

  • Genetics
  • Molecular Biology
  • Genetics(clinical)
  • Cell Biology

Cite this

Mapping of the human Zn-a2-glycoprotein gene (AZGP1) to chromosome 7q22 by in situ hybridization. / Pendás, A. M.; Matilla, T.; Uría, J. A.; Freije, J. P.; Fueyo, A.; Estivill, Xavier P.; López-Otín, Carlos.

In: Cytogenetic and Genome Research, Vol. 66, No. 4, 1994, p. 263-266.

Research output: Contribution to journalArticle

Pendás, AM, Matilla, T, Uría, JA, Freije, JP, Fueyo, A, Estivill, XP & López-Otín, C 1994, 'Mapping of the human Zn-a2-glycoprotein gene (AZGP1) to chromosome 7q22 by in situ hybridization', Cytogenetic and Genome Research, vol. 66, no. 4, pp. 263-266. https://doi.org/10.1159/000133708
Pendás, A. M. ; Matilla, T. ; Uría, J. A. ; Freije, J. P. ; Fueyo, A. ; Estivill, Xavier P. ; López-Otín, Carlos. / Mapping of the human Zn-a2-glycoprotein gene (AZGP1) to chromosome 7q22 by in situ hybridization. In: Cytogenetic and Genome Research. 1994 ; Vol. 66, No. 4. pp. 263-266.
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