Mapping of the human Zn-a2-glycoprotein gene (AZGP1) to chromosome 7q22 by in situ hybridization

A. M. Pendás, T. Matilla, J. A. Uría, J. P. Freije, A. Fueyo, Xavier P. Estivill, Carlos López-Otín

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The gene coding for Zn-α2-glycoprotein (AZGPI), a human protein with a high degree of similarity to class I major histocompatibility complex (MHC) antigens, was mapped by fluorescent in situ hybridization to chromosome 7q22. a common breakpoint in myelodysplastic syndromes. Since classical MHC genes map on chromosome 6, this assignment indicates that besides duplication of the putative common ancestor gene, transposition events to different chromosomes have also been involved in the evolutionary diversification of this gene family.

Original languageEnglish
Pages (from-to)263-266
Number of pages4
JournalCytogenetic and Genome Research
Issue number4
Publication statusPublished - 1994
Externally publishedYes


ASJC Scopus subject areas

  • Genetics
  • Molecular Biology
  • Genetics(clinical)
  • Cell Biology

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