Mapping of NPR-B immunoreactivity in the brainstem of Macaca fascicularis

Essam Mohamed, Ikuo Tooyama

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

C-type natriuretic peptide (CNP), the most abundant natriuretic peptide hormone in the brain, plays an important role in neuroendocrine function. The physiological effects of CNP are mediated by the natriuretic peptide receptor-B (NPR-B). Although CNP and NPR-B have been detected in several brain regions, little is known about the neuroanatomical localization of NPR-B protein in the brainstem. In the present study, we investigated the topographical distribution of NPR-B immunoreactivity in the monkey brainstem. The data demonstrate widespread NPR-B immunoreactivity throughout the brainstem. NPR-B immunoreactivity was located in the superior colliculus, inferior colliculus, periaqueductal gray, oculomotor nucleus, red nucleus, ventral tegmental area, substantia nigra, and cerebral peduncle of the midbrain, as well as in the abducens nucleus, medial vestibular nucleus, lateral vestibular nucleus, parabrachial nucleus, locus coeruleus, trigeminal motor nucleus, pontine reticular nucleus, facial nucleus, oral part of the spinal trigeminal nucleus, cochlear nucleus, raphe magnus nucleus, raphe pallidus nucleus, pontine nucleus of the pons, the dorsal motor nucleus of the vagus, hypoglossal nucleus, nucleus tractus solitarius, gracile nucleus, cuneate nucleus, medial vestibular nucleus, spinal trigeminal nucleus, nucleus ambiguus, lateral paragigantocellular nucleus, lateral reticular nucleus, and the inferior olivary nucleus of the medulla oblongata. The widespread distribution of NPR-B-immunoreactive structures throughout the monkey brainstem indicates that CNP may be involved in several physiological mechanisms, acting as a neurotransmitter and/or neuromodulator.

Original languageEnglish
Pages (from-to)387-402
Number of pages16
JournalBrain Structure and Function
Volume216
Issue number4
DOIs
Publication statusPublished - 1 Nov 2011
Externally publishedYes

Fingerprint

Macaca fascicularis
Brain Stem
C-Type Natriuretic Peptide
Spinal Trigeminal Nucleus
Vestibular Nuclei
Inferior Colliculi
Medulla Oblongata
Raphe Nuclei
Haplorhini
Neurotransmitter Agents
Lateral Vestibular Nucleus
Olivary Nucleus
Red Nucleus
Cochlear Nucleus
Periaqueductal Gray
Natriuretic Peptides
Ventral Tegmental Area
Solitary Nucleus
Locus Coeruleus
Pons

Keywords

  • Medulla
  • Midbrain
  • Neuropeptide
  • NPR-.B.
  • Pons
  • Primates

ASJC Scopus subject areas

  • Anatomy
  • Histology
  • Neuroscience(all)

Cite this

Mapping of NPR-B immunoreactivity in the brainstem of Macaca fascicularis. / Mohamed, Essam; Tooyama, Ikuo.

In: Brain Structure and Function, Vol. 216, No. 4, 01.11.2011, p. 387-402.

Research output: Contribution to journalArticle

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