Mapping human genetic diversity in Asia

Mahmood Ameen Abdulla, Ikhlak Ahmed, Anunchai Assawamakin, Jong Bhak, Samir K. Brahmachari, Gayvelline C. Calacal, Amit Chaurasia, Chien Hsiun Chen, Jieming Chen, Yuan Tsong Chen, Jiayou Chu, Eva Maria C. Cutiongco-de La Paz, Maria Corazon A. De Ungria, Frederick C. Delfin, Juli Edo, Suthat Fuchareon, Ho Ghang, Takashi Gojobori, Junsong Han, Sheng Feng Ho & 72 others Boon Peng Hoh, Wei Huang, Hidetoshi Inoko, Pankaj Jha, Timothy A. Jinam, Li Jin, Jongsun Jung, Daoroong Kangwanpong, Jatupol Kampuansai, Giulia C. Kennedy, Preeti Khurana, Hyung Lae Kim, Kwangjoong Kim, Sangsoo Kim, Woo Yeon Kim, Kuchan Kimm, Ryosuke Kimura, Tomohiro Koike, Supasak Kulawonganunchai, Vikrant Kumar, Poh San Lai, Jong Young Lee, Sunghoon Lee, Edison T. Liu, Partha P. Majumder, Kiran Kumar Mandapati, Sangkot Marzuki, Wayne Mitchell, Mitali Mukerji, Kenji Naritomi, Chumpol Ngamphiw, Norio Niikawa, Nao Nishida, Bermseok Oh, Sangho Oh, Jun Ohashi, Akira Oka, Rick Ong, Carmencita D. Padilla, Prasit Palittapongarnpim, Henry B. Perdigon, Maude Elvira Phipps, Eileen Png, Yoshiyuki Sakaki, Jazelyn M. Salvador, Yuliana Sandraling, Vinod Scaria, Mark Seielstad, Mohd Ros Sidek, Amit Sinha, Metawee Srikummool, Herawati Sudoyo, Sumio Sugano, Helena Suryadi, Yoshiyuki Suzuki, Kristina A. Tabbada, Adrian Tan, Katsushi Tokunaga, Sissades Tongsima, Lilian P. Villamor, Eric Wang, Ying Wang, Haifeng Wang, Jer Yuarn Wu, Huasheng Xiao, Shuhua Xu, Jin Ok Yang, Yin Yao Shugart, Hyang Sook Yoo, Wentao Yuan, Guoping Zhao, Bin Alwi Zilfalil

Research output: Contribution to journalArticle

332 Citations (Scopus)

Abstract

Asia harbors substantial cultural and linguistic diversity, but the geographic structure of genetic variation across the continent remains enigmatic. Here we report a large-scale survey of autosomal variation from a broad geographic sample of Asian human populations. Our results show that genetic ancestry is strongly correlated with linguistic affiliations as well as geography. Most populations show relatedness within ethnic/linguistic groups, despite prevalent gene flow among populations. More than 90% of East Asian (EA) haplotypes could be found in either Southeast Asian (SEA) or Central-South Asian (CSA) populations and show clinal structure with haplotype diversity decreasing from south to north. Furthermore, 50% of EA haplotypes were found in SEA only and 5% were found in CSA only, indicating that SEA was a major geographic source of EA populations.

Original languageEnglish
Pages (from-to)1541-1545
Number of pages5
JournalScience
Volume326
Issue number5959
DOIs
Publication statusPublished - 11 Dec 2009
Externally publishedYes

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Medical Genetics
Linguistics
Haplotypes
Population
Cultural Diversity
Geography
Gene Flow
Ethnic Groups

ASJC Scopus subject areas

  • General

Cite this

Abdulla, M. A., Ahmed, I., Assawamakin, A., Bhak, J., Brahmachari, S. K., Calacal, G. C., ... Zilfalil, B. A. (2009). Mapping human genetic diversity in Asia. Science, 326(5959), 1541-1545. https://doi.org/10.1126/science.1177074

Mapping human genetic diversity in Asia. / Abdulla, Mahmood Ameen; Ahmed, Ikhlak; Assawamakin, Anunchai; Bhak, Jong; Brahmachari, Samir K.; Calacal, Gayvelline C.; Chaurasia, Amit; Chen, Chien Hsiun; Chen, Jieming; Chen, Yuan Tsong; Chu, Jiayou; Cutiongco-de La Paz, Eva Maria C.; De Ungria, Maria Corazon A.; Delfin, Frederick C.; Edo, Juli; Fuchareon, Suthat; Ghang, Ho; Gojobori, Takashi; Han, Junsong; Ho, Sheng Feng; Hoh, Boon Peng; Huang, Wei; Inoko, Hidetoshi; Jha, Pankaj; Jinam, Timothy A.; Jin, Li; Jung, Jongsun; Kangwanpong, Daoroong; Kampuansai, Jatupol; Kennedy, Giulia C.; Khurana, Preeti; Kim, Hyung Lae; Kim, Kwangjoong; Kim, Sangsoo; Kim, Woo Yeon; Kimm, Kuchan; Kimura, Ryosuke; Koike, Tomohiro; Kulawonganunchai, Supasak; Kumar, Vikrant; Lai, Poh San; Lee, Jong Young; Lee, Sunghoon; Liu, Edison T.; Majumder, Partha P.; Mandapati, Kiran Kumar; Marzuki, Sangkot; Mitchell, Wayne; Mukerji, Mitali; Naritomi, Kenji; Ngamphiw, Chumpol; Niikawa, Norio; Nishida, Nao; Oh, Bermseok; Oh, Sangho; Ohashi, Jun; Oka, Akira; Ong, Rick; Padilla, Carmencita D.; Palittapongarnpim, Prasit; Perdigon, Henry B.; Phipps, Maude Elvira; Png, Eileen; Sakaki, Yoshiyuki; Salvador, Jazelyn M.; Sandraling, Yuliana; Scaria, Vinod; Seielstad, Mark; Sidek, Mohd Ros; Sinha, Amit; Srikummool, Metawee; Sudoyo, Herawati; Sugano, Sumio; Suryadi, Helena; Suzuki, Yoshiyuki; Tabbada, Kristina A.; Tan, Adrian; Tokunaga, Katsushi; Tongsima, Sissades; Villamor, Lilian P.; Wang, Eric; Wang, Ying; Wang, Haifeng; Wu, Jer Yuarn; Xiao, Huasheng; Xu, Shuhua; Yang, Jin Ok; Shugart, Yin Yao; Yoo, Hyang Sook; Yuan, Wentao; Zhao, Guoping; Zilfalil, Bin Alwi.

In: Science, Vol. 326, No. 5959, 11.12.2009, p. 1541-1545.

Research output: Contribution to journalArticle

Abdulla, MA, Ahmed, I, Assawamakin, A, Bhak, J, Brahmachari, SK, Calacal, GC, Chaurasia, A, Chen, CH, Chen, J, Chen, YT, Chu, J, Cutiongco-de La Paz, EMC, De Ungria, MCA, Delfin, FC, Edo, J, Fuchareon, S, Ghang, H, Gojobori, T, Han, J, Ho, SF, Hoh, BP, Huang, W, Inoko, H, Jha, P, Jinam, TA, Jin, L, Jung, J, Kangwanpong, D, Kampuansai, J, Kennedy, GC, Khurana, P, Kim, HL, Kim, K, Kim, S, Kim, WY, Kimm, K, Kimura, R, Koike, T, Kulawonganunchai, S, Kumar, V, Lai, PS, Lee, JY, Lee, S, Liu, ET, Majumder, PP, Mandapati, KK, Marzuki, S, Mitchell, W, Mukerji, M, Naritomi, K, Ngamphiw, C, Niikawa, N, Nishida, N, Oh, B, Oh, S, Ohashi, J, Oka, A, Ong, R, Padilla, CD, Palittapongarnpim, P, Perdigon, HB, Phipps, ME, Png, E, Sakaki, Y, Salvador, JM, Sandraling, Y, Scaria, V, Seielstad, M, Sidek, MR, Sinha, A, Srikummool, M, Sudoyo, H, Sugano, S, Suryadi, H, Suzuki, Y, Tabbada, KA, Tan, A, Tokunaga, K, Tongsima, S, Villamor, LP, Wang, E, Wang, Y, Wang, H, Wu, JY, Xiao, H, Xu, S, Yang, JO, Shugart, YY, Yoo, HS, Yuan, W, Zhao, G & Zilfalil, BA 2009, 'Mapping human genetic diversity in Asia', Science, vol. 326, no. 5959, pp. 1541-1545. https://doi.org/10.1126/science.1177074
Abdulla MA, Ahmed I, Assawamakin A, Bhak J, Brahmachari SK, Calacal GC et al. Mapping human genetic diversity in Asia. Science. 2009 Dec 11;326(5959):1541-1545. https://doi.org/10.1126/science.1177074
Abdulla, Mahmood Ameen ; Ahmed, Ikhlak ; Assawamakin, Anunchai ; Bhak, Jong ; Brahmachari, Samir K. ; Calacal, Gayvelline C. ; Chaurasia, Amit ; Chen, Chien Hsiun ; Chen, Jieming ; Chen, Yuan Tsong ; Chu, Jiayou ; Cutiongco-de La Paz, Eva Maria C. ; De Ungria, Maria Corazon A. ; Delfin, Frederick C. ; Edo, Juli ; Fuchareon, Suthat ; Ghang, Ho ; Gojobori, Takashi ; Han, Junsong ; Ho, Sheng Feng ; Hoh, Boon Peng ; Huang, Wei ; Inoko, Hidetoshi ; Jha, Pankaj ; Jinam, Timothy A. ; Jin, Li ; Jung, Jongsun ; Kangwanpong, Daoroong ; Kampuansai, Jatupol ; Kennedy, Giulia C. ; Khurana, Preeti ; Kim, Hyung Lae ; Kim, Kwangjoong ; Kim, Sangsoo ; Kim, Woo Yeon ; Kimm, Kuchan ; Kimura, Ryosuke ; Koike, Tomohiro ; Kulawonganunchai, Supasak ; Kumar, Vikrant ; Lai, Poh San ; Lee, Jong Young ; Lee, Sunghoon ; Liu, Edison T. ; Majumder, Partha P. ; Mandapati, Kiran Kumar ; Marzuki, Sangkot ; Mitchell, Wayne ; Mukerji, Mitali ; Naritomi, Kenji ; Ngamphiw, Chumpol ; Niikawa, Norio ; Nishida, Nao ; Oh, Bermseok ; Oh, Sangho ; Ohashi, Jun ; Oka, Akira ; Ong, Rick ; Padilla, Carmencita D. ; Palittapongarnpim, Prasit ; Perdigon, Henry B. ; Phipps, Maude Elvira ; Png, Eileen ; Sakaki, Yoshiyuki ; Salvador, Jazelyn M. ; Sandraling, Yuliana ; Scaria, Vinod ; Seielstad, Mark ; Sidek, Mohd Ros ; Sinha, Amit ; Srikummool, Metawee ; Sudoyo, Herawati ; Sugano, Sumio ; Suryadi, Helena ; Suzuki, Yoshiyuki ; Tabbada, Kristina A. ; Tan, Adrian ; Tokunaga, Katsushi ; Tongsima, Sissades ; Villamor, Lilian P. ; Wang, Eric ; Wang, Ying ; Wang, Haifeng ; Wu, Jer Yuarn ; Xiao, Huasheng ; Xu, Shuhua ; Yang, Jin Ok ; Shugart, Yin Yao ; Yoo, Hyang Sook ; Yuan, Wentao ; Zhao, Guoping ; Zilfalil, Bin Alwi. / Mapping human genetic diversity in Asia. In: Science. 2009 ; Vol. 326, No. 5959. pp. 1541-1545.
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title = "Mapping human genetic diversity in Asia",
abstract = "Asia harbors substantial cultural and linguistic diversity, but the geographic structure of genetic variation across the continent remains enigmatic. Here we report a large-scale survey of autosomal variation from a broad geographic sample of Asian human populations. Our results show that genetic ancestry is strongly correlated with linguistic affiliations as well as geography. Most populations show relatedness within ethnic/linguistic groups, despite prevalent gene flow among populations. More than 90{\%} of East Asian (EA) haplotypes could be found in either Southeast Asian (SEA) or Central-South Asian (CSA) populations and show clinal structure with haplotype diversity decreasing from south to north. Furthermore, 50{\%} of EA haplotypes were found in SEA only and 5{\%} were found in CSA only, indicating that SEA was a major geographic source of EA populations.",
author = "Abdulla, {Mahmood Ameen} and Ikhlak Ahmed and Anunchai Assawamakin and Jong Bhak and Brahmachari, {Samir K.} and Calacal, {Gayvelline C.} and Amit Chaurasia and Chen, {Chien Hsiun} and Jieming Chen and Chen, {Yuan Tsong} and Jiayou Chu and {Cutiongco-de La Paz}, {Eva Maria C.} and {De Ungria}, {Maria Corazon A.} and Delfin, {Frederick C.} and Juli Edo and Suthat Fuchareon and Ho Ghang and Takashi Gojobori and Junsong Han and Ho, {Sheng Feng} and Hoh, {Boon Peng} and Wei Huang and Hidetoshi Inoko and Pankaj Jha and Jinam, {Timothy A.} and Li Jin and Jongsun Jung and Daoroong Kangwanpong and Jatupol Kampuansai and Kennedy, {Giulia C.} and Preeti Khurana and Kim, {Hyung Lae} and Kwangjoong Kim and Sangsoo Kim and Kim, {Woo Yeon} and Kuchan Kimm and Ryosuke Kimura and Tomohiro Koike and Supasak Kulawonganunchai and Vikrant Kumar and Lai, {Poh San} and Lee, {Jong Young} and Sunghoon Lee and Liu, {Edison T.} and Majumder, {Partha P.} and Mandapati, {Kiran Kumar} and Sangkot Marzuki and Wayne Mitchell and Mitali Mukerji and Kenji Naritomi and Chumpol Ngamphiw and Norio Niikawa and Nao Nishida and Bermseok Oh and Sangho Oh and Jun Ohashi and Akira Oka and Rick Ong and Padilla, {Carmencita D.} and Prasit Palittapongarnpim and Perdigon, {Henry B.} and Phipps, {Maude Elvira} and Eileen Png and Yoshiyuki Sakaki and Salvador, {Jazelyn M.} and Yuliana Sandraling and Vinod Scaria and Mark Seielstad and Sidek, {Mohd Ros} and Amit Sinha and Metawee Srikummool and Herawati Sudoyo and Sumio Sugano and Helena Suryadi and Yoshiyuki Suzuki and Tabbada, {Kristina A.} and Adrian Tan and Katsushi Tokunaga and Sissades Tongsima and Villamor, {Lilian P.} and Eric Wang and Ying Wang and Haifeng Wang and Wu, {Jer Yuarn} and Huasheng Xiao and Shuhua Xu and Yang, {Jin Ok} and Shugart, {Yin Yao} and Yoo, {Hyang Sook} and Wentao Yuan and Guoping Zhao and Zilfalil, {Bin Alwi}",
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TY - JOUR

T1 - Mapping human genetic diversity in Asia

AU - Abdulla, Mahmood Ameen

AU - Ahmed, Ikhlak

AU - Assawamakin, Anunchai

AU - Bhak, Jong

AU - Brahmachari, Samir K.

AU - Calacal, Gayvelline C.

AU - Chaurasia, Amit

AU - Chen, Chien Hsiun

AU - Chen, Jieming

AU - Chen, Yuan Tsong

AU - Chu, Jiayou

AU - Cutiongco-de La Paz, Eva Maria C.

AU - De Ungria, Maria Corazon A.

AU - Delfin, Frederick C.

AU - Edo, Juli

AU - Fuchareon, Suthat

AU - Ghang, Ho

AU - Gojobori, Takashi

AU - Han, Junsong

AU - Ho, Sheng Feng

AU - Hoh, Boon Peng

AU - Huang, Wei

AU - Inoko, Hidetoshi

AU - Jha, Pankaj

AU - Jinam, Timothy A.

AU - Jin, Li

AU - Jung, Jongsun

AU - Kangwanpong, Daoroong

AU - Kampuansai, Jatupol

AU - Kennedy, Giulia C.

AU - Khurana, Preeti

AU - Kim, Hyung Lae

AU - Kim, Kwangjoong

AU - Kim, Sangsoo

AU - Kim, Woo Yeon

AU - Kimm, Kuchan

AU - Kimura, Ryosuke

AU - Koike, Tomohiro

AU - Kulawonganunchai, Supasak

AU - Kumar, Vikrant

AU - Lai, Poh San

AU - Lee, Jong Young

AU - Lee, Sunghoon

AU - Liu, Edison T.

AU - Majumder, Partha P.

AU - Mandapati, Kiran Kumar

AU - Marzuki, Sangkot

AU - Mitchell, Wayne

AU - Mukerji, Mitali

AU - Naritomi, Kenji

AU - Ngamphiw, Chumpol

AU - Niikawa, Norio

AU - Nishida, Nao

AU - Oh, Bermseok

AU - Oh, Sangho

AU - Ohashi, Jun

AU - Oka, Akira

AU - Ong, Rick

AU - Padilla, Carmencita D.

AU - Palittapongarnpim, Prasit

AU - Perdigon, Henry B.

AU - Phipps, Maude Elvira

AU - Png, Eileen

AU - Sakaki, Yoshiyuki

AU - Salvador, Jazelyn M.

AU - Sandraling, Yuliana

AU - Scaria, Vinod

AU - Seielstad, Mark

AU - Sidek, Mohd Ros

AU - Sinha, Amit

AU - Srikummool, Metawee

AU - Sudoyo, Herawati

AU - Sugano, Sumio

AU - Suryadi, Helena

AU - Suzuki, Yoshiyuki

AU - Tabbada, Kristina A.

AU - Tan, Adrian

AU - Tokunaga, Katsushi

AU - Tongsima, Sissades

AU - Villamor, Lilian P.

AU - Wang, Eric

AU - Wang, Ying

AU - Wang, Haifeng

AU - Wu, Jer Yuarn

AU - Xiao, Huasheng

AU - Xu, Shuhua

AU - Yang, Jin Ok

AU - Shugart, Yin Yao

AU - Yoo, Hyang Sook

AU - Yuan, Wentao

AU - Zhao, Guoping

AU - Zilfalil, Bin Alwi

PY - 2009/12/11

Y1 - 2009/12/11

N2 - Asia harbors substantial cultural and linguistic diversity, but the geographic structure of genetic variation across the continent remains enigmatic. Here we report a large-scale survey of autosomal variation from a broad geographic sample of Asian human populations. Our results show that genetic ancestry is strongly correlated with linguistic affiliations as well as geography. Most populations show relatedness within ethnic/linguistic groups, despite prevalent gene flow among populations. More than 90% of East Asian (EA) haplotypes could be found in either Southeast Asian (SEA) or Central-South Asian (CSA) populations and show clinal structure with haplotype diversity decreasing from south to north. Furthermore, 50% of EA haplotypes were found in SEA only and 5% were found in CSA only, indicating that SEA was a major geographic source of EA populations.

AB - Asia harbors substantial cultural and linguistic diversity, but the geographic structure of genetic variation across the continent remains enigmatic. Here we report a large-scale survey of autosomal variation from a broad geographic sample of Asian human populations. Our results show that genetic ancestry is strongly correlated with linguistic affiliations as well as geography. Most populations show relatedness within ethnic/linguistic groups, despite prevalent gene flow among populations. More than 90% of East Asian (EA) haplotypes could be found in either Southeast Asian (SEA) or Central-South Asian (CSA) populations and show clinal structure with haplotype diversity decreasing from south to north. Furthermore, 50% of EA haplotypes were found in SEA only and 5% were found in CSA only, indicating that SEA was a major geographic source of EA populations.

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