Malignant exophthalmos associated with multiple myeloma

Akira Seya, Takashi Terano, Yoko Hattori, Takuya Tomizuka, Hiroshi Morio, Tomoshige Kino, Aizan Hirai, Yasushi Tamura, Sho Yoshida, Tetsuo Nishikawa

Research output: Contribution to journalArticle

2 Citations (Scopus)


We report a patient with malignant exophthalmos associated with multiple myelomawhich showed no evidence of direct orbital involvement of plasma cells. This exophthalmos had similarities with Graves' ophthalmopathy, but the patient had no detectable autoimmune thyroid diseases. Plasmapheresis was effective not only for the treatment of heart and renal failure due to the myeloma kidney but also for the malignant exophthalmos. As the serum monoclonal IgG level was decreased by plasmapheresis, the improvement of proptosis, visual acuity, and hypertrophy of the extraocular muscle as measured by magnetic resonance imaging were observed. It is suggested that humoral factors removed by plasmapheresis might be involved in the pathogenesis of this nonendocrine exophthalmos.

Original languageEnglish
Pages (from-to)875-878
Number of pages4
JournalInternal Medicine
Issue number11
Publication statusPublished - 1993
Externally publishedYes



  • Graves' ophthalmopathy
  • plasmapheresis

ASJC Scopus subject areas

  • Internal Medicine

Cite this

Seya, A., Terano, T., Hattori, Y., Tomizuka, T., Morio, H., Kino, T., Hirai, A., Tamura, Y., Yoshida, S., & Nishikawa, T. (1993). Malignant exophthalmos associated with multiple myeloma. Internal Medicine, 32(11), 875-878.