Malignant exophthalmos associated with multiple myeloma

Akira Seya, Takashi Terano, Yoko Hattori, Takuya Tomizuka, Hiroshi Morio, Tomoshige Kino, Aizan Hirai, Yasushi Tamura, Sho Yoshida, Tetsuo Nishikawa

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

We report a patient with malignant exophthalmos associated with multiple myelomawhich showed no evidence of direct orbital involvement of plasma cells. This exophthalmos had similarities with Graves' ophthalmopathy, but the patient had no detectable autoimmune thyroid diseases. Plasmapheresis was effective not only for the treatment of heart and renal failure due to the myeloma kidney but also for the malignant exophthalmos. As the serum monoclonal IgG level was decreased by plasmapheresis, the improvement of proptosis, visual acuity, and hypertrophy of the extraocular muscle as measured by magnetic resonance imaging were observed. It is suggested that humoral factors removed by plasmapheresis might be involved in the pathogenesis of this nonendocrine exophthalmos.

Original languageEnglish
Pages (from-to)875-878
Number of pages4
JournalInternal Medicine
Volume32
Issue number11
DOIs
Publication statusPublished - 1993
Externally publishedYes

Fingerprint

Exophthalmos
Multiple Myeloma
Plasmapheresis
Oculomotor Muscles
Graves Ophthalmopathy
Thyroid Diseases
Plasma Cells
Treatment Failure
Hypertrophy
Autoimmune Diseases
Visual Acuity
Renal Insufficiency
Heart Failure
Immunoglobulin G
Magnetic Resonance Imaging
Kidney
Serum

Keywords

  • Graves' ophthalmopathy
  • plasmapheresis

ASJC Scopus subject areas

  • Internal Medicine

Cite this

Seya, A., Terano, T., Hattori, Y., Tomizuka, T., Morio, H., Kino, T., ... Nishikawa, T. (1993). Malignant exophthalmos associated with multiple myeloma. Internal Medicine, 32(11), 875-878. https://doi.org/10.2169/internalmedicine.32.875

Malignant exophthalmos associated with multiple myeloma. / Seya, Akira; Terano, Takashi; Hattori, Yoko; Tomizuka, Takuya; Morio, Hiroshi; Kino, Tomoshige; Hirai, Aizan; Tamura, Yasushi; Yoshida, Sho; Nishikawa, Tetsuo.

In: Internal Medicine, Vol. 32, No. 11, 1993, p. 875-878.

Research output: Contribution to journalArticle

Seya, A, Terano, T, Hattori, Y, Tomizuka, T, Morio, H, Kino, T, Hirai, A, Tamura, Y, Yoshida, S & Nishikawa, T 1993, 'Malignant exophthalmos associated with multiple myeloma', Internal Medicine, vol. 32, no. 11, pp. 875-878. https://doi.org/10.2169/internalmedicine.32.875
Seya, Akira ; Terano, Takashi ; Hattori, Yoko ; Tomizuka, Takuya ; Morio, Hiroshi ; Kino, Tomoshige ; Hirai, Aizan ; Tamura, Yasushi ; Yoshida, Sho ; Nishikawa, Tetsuo. / Malignant exophthalmos associated with multiple myeloma. In: Internal Medicine. 1993 ; Vol. 32, No. 11. pp. 875-878.
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