Main roads to melanoma

Giuseppe Palmieri, Mariaelena Capone, Maria L. Ascierto, Giusy Gentilcore, David F. Stroncek, Milena Casula, Maria C. Sini, Marco Palla, Nicola Mozzillo, Paolo A. Ascierto

Research output: Contribution to journalReview article

120 Citations (Scopus)

Abstract

The characterization of the molecular mechanisms involved in development and progression of melanoma could be helpful to identify the molecular profiles underlying aggressiveness, clinical behavior, and response to therapy as well as to better classify the subsets of melanoma patients with different prognosis and/or clinical outcome. Actually, some aspects regarding the main molecular changes responsible for the onset as well as the progression of melanoma toward a more aggressive phenotype have been described. Genes and molecules which control either cell proliferation, apoptosis, or cell senescence have been implicated. Here we provided an overview of the main molecular changes underlying the pathogenesis of melanoma. All evidence clearly indicates the existence of a complex molecular machinery that provides checks and balances in normal melanocytes. Progression from normal melanocytes to malignant metastatic cells in melanoma patients is the result of a combination of down- or up-regulation of various effectors acting on different molecular pathways.

Original languageEnglish
Article number86
JournalJournal of Translational Medicine
Volume7
DOIs
Publication statusPublished - 14 Oct 2009
Externally publishedYes

Fingerprint

Cell proliferation
Machinery
Melanoma
Genes
Apoptosis
Molecules
Melanocytes
Cell Aging
Up-Regulation
Down-Regulation
Cell Proliferation
Phenotype

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Palmieri, G., Capone, M., Ascierto, M. L., Gentilcore, G., Stroncek, D. F., Casula, M., ... Ascierto, P. A. (2009). Main roads to melanoma. Journal of Translational Medicine, 7, [86]. https://doi.org/10.1186/1479-5876-7-86

Main roads to melanoma. / Palmieri, Giuseppe; Capone, Mariaelena; Ascierto, Maria L.; Gentilcore, Giusy; Stroncek, David F.; Casula, Milena; Sini, Maria C.; Palla, Marco; Mozzillo, Nicola; Ascierto, Paolo A.

In: Journal of Translational Medicine, Vol. 7, 86, 14.10.2009.

Research output: Contribution to journalReview article

Palmieri, G, Capone, M, Ascierto, ML, Gentilcore, G, Stroncek, DF, Casula, M, Sini, MC, Palla, M, Mozzillo, N & Ascierto, PA 2009, 'Main roads to melanoma', Journal of Translational Medicine, vol. 7, 86. https://doi.org/10.1186/1479-5876-7-86
Palmieri G, Capone M, Ascierto ML, Gentilcore G, Stroncek DF, Casula M et al. Main roads to melanoma. Journal of Translational Medicine. 2009 Oct 14;7. 86. https://doi.org/10.1186/1479-5876-7-86
Palmieri, Giuseppe ; Capone, Mariaelena ; Ascierto, Maria L. ; Gentilcore, Giusy ; Stroncek, David F. ; Casula, Milena ; Sini, Maria C. ; Palla, Marco ; Mozzillo, Nicola ; Ascierto, Paolo A. / Main roads to melanoma. In: Journal of Translational Medicine. 2009 ; Vol. 7.
@article{aeeedf592fad4ec1a10bbeb83694f4bb,
title = "Main roads to melanoma",
abstract = "The characterization of the molecular mechanisms involved in development and progression of melanoma could be helpful to identify the molecular profiles underlying aggressiveness, clinical behavior, and response to therapy as well as to better classify the subsets of melanoma patients with different prognosis and/or clinical outcome. Actually, some aspects regarding the main molecular changes responsible for the onset as well as the progression of melanoma toward a more aggressive phenotype have been described. Genes and molecules which control either cell proliferation, apoptosis, or cell senescence have been implicated. Here we provided an overview of the main molecular changes underlying the pathogenesis of melanoma. All evidence clearly indicates the existence of a complex molecular machinery that provides checks and balances in normal melanocytes. Progression from normal melanocytes to malignant metastatic cells in melanoma patients is the result of a combination of down- or up-regulation of various effectors acting on different molecular pathways.",
author = "Giuseppe Palmieri and Mariaelena Capone and Ascierto, {Maria L.} and Giusy Gentilcore and Stroncek, {David F.} and Milena Casula and Sini, {Maria C.} and Marco Palla and Nicola Mozzillo and Ascierto, {Paolo A.}",
year = "2009",
month = "10",
day = "14",
doi = "10.1186/1479-5876-7-86",
language = "English",
volume = "7",
journal = "Journal of Translational Medicine",
issn = "1479-5876",
publisher = "BioMed Central",

}

TY - JOUR

T1 - Main roads to melanoma

AU - Palmieri, Giuseppe

AU - Capone, Mariaelena

AU - Ascierto, Maria L.

AU - Gentilcore, Giusy

AU - Stroncek, David F.

AU - Casula, Milena

AU - Sini, Maria C.

AU - Palla, Marco

AU - Mozzillo, Nicola

AU - Ascierto, Paolo A.

PY - 2009/10/14

Y1 - 2009/10/14

N2 - The characterization of the molecular mechanisms involved in development and progression of melanoma could be helpful to identify the molecular profiles underlying aggressiveness, clinical behavior, and response to therapy as well as to better classify the subsets of melanoma patients with different prognosis and/or clinical outcome. Actually, some aspects regarding the main molecular changes responsible for the onset as well as the progression of melanoma toward a more aggressive phenotype have been described. Genes and molecules which control either cell proliferation, apoptosis, or cell senescence have been implicated. Here we provided an overview of the main molecular changes underlying the pathogenesis of melanoma. All evidence clearly indicates the existence of a complex molecular machinery that provides checks and balances in normal melanocytes. Progression from normal melanocytes to malignant metastatic cells in melanoma patients is the result of a combination of down- or up-regulation of various effectors acting on different molecular pathways.

AB - The characterization of the molecular mechanisms involved in development and progression of melanoma could be helpful to identify the molecular profiles underlying aggressiveness, clinical behavior, and response to therapy as well as to better classify the subsets of melanoma patients with different prognosis and/or clinical outcome. Actually, some aspects regarding the main molecular changes responsible for the onset as well as the progression of melanoma toward a more aggressive phenotype have been described. Genes and molecules which control either cell proliferation, apoptosis, or cell senescence have been implicated. Here we provided an overview of the main molecular changes underlying the pathogenesis of melanoma. All evidence clearly indicates the existence of a complex molecular machinery that provides checks and balances in normal melanocytes. Progression from normal melanocytes to malignant metastatic cells in melanoma patients is the result of a combination of down- or up-regulation of various effectors acting on different molecular pathways.

UR - http://www.scopus.com/inward/record.url?scp=71149083533&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=71149083533&partnerID=8YFLogxK

U2 - 10.1186/1479-5876-7-86

DO - 10.1186/1479-5876-7-86

M3 - Review article

C2 - 19828018

AN - SCOPUS:71149083533

VL - 7

JO - Journal of Translational Medicine

JF - Journal of Translational Medicine

SN - 1479-5876

M1 - 86

ER -