Magnetic hyperthermia study of Mn-Zn-Fe and Zn-Gd-Fe nanoparticle systems as possible low-Tc agents for magnetic particle hyperthermia

Saleh S. Hayek, Ching Jen Chen, Glen Pores, Christopher D. Batich, Yousef Haik

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Manganese zinc iron and zinc gadolinium iron magnetic nanoparticles were synthesized by chemical methods and by co-precipitation process. The particles were further encapsulated with a biodegradable polymer, PEG. The particles have a Curie temperature (T c) in the range of 43-46°C and are designed to be used for magnetic hyperthermia application, one of the many therapy options for cancer treatment. Morphology and magnetic properties of these encapsulated nanoparticles were determined by TEM, XRD and SQUID. Curie temperatures for the alloy particles and encapsulated particles were also measured. The AC magnetic heating pattern of particles at ̃ 961 KHz using alcohol thermometer is presented. The frequency dependence of the heating follows general trends predicted by power loss equations and is similar to traditional materials. In conclusion, quality heating particles were synthesized and shown to generate sufficient heating at room temperature and self-controlled by their respective Curie temperatures.

Original languageEnglish
Title of host publicationMaterials Research Society Symposium Proceedings - Engineered Nanoscale Materials for the Diagnosis and Treatment of Disease
Pages62-75
Number of pages14
Volume1019
Publication statusPublished - 2007
Externally publishedYes
EventEngineered Nanoscale Materials for the Diagnosis and Treatment of Disease - 2007 MRS Spring Meeting - San Francisco, CA, United States
Duration: 9 Apr 200713 Apr 2007

Other

OtherEngineered Nanoscale Materials for the Diagnosis and Treatment of Disease - 2007 MRS Spring Meeting
CountryUnited States
CitySan Francisco, CA
Period9/4/0713/4/07

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ASJC Scopus subject areas

  • Materials Science(all)
  • Condensed Matter Physics
  • Mechanics of Materials
  • Mechanical Engineering

Cite this

Hayek, S. S., Chen, C. J., Pores, G., Batich, C. D., & Haik, Y. (2007). Magnetic hyperthermia study of Mn-Zn-Fe and Zn-Gd-Fe nanoparticle systems as possible low-Tc agents for magnetic particle hyperthermia. In Materials Research Society Symposium Proceedings - Engineered Nanoscale Materials for the Diagnosis and Treatment of Disease (Vol. 1019, pp. 62-75)