Macaque model for severe acute respiratory syndrome

Thomas Rowe, Guangping Gao, Robert J. Hogan, Ronald G. Crystal, Thomas G. Voss, Rebecca L. Grant, Peter Bell, Gary P. Kobinger, Nelson A. Wivel, James M. Wilson

Research output: Contribution to journalArticle

71 Citations (Scopus)

Abstract

Rhesus and cynomolgus macaques were challenged with 107 PFU of a clinical isolate of the severe acute respiratory syndrome (SARS) coronavirus. Some of the animals developed a mild self-limited respiratory infection very different from that observed in humans with SARS. The macaque model as it currently exists will have limited utility in the study of SARS and the evaluation of therapies.

Original languageEnglish
Pages (from-to)11401-11404
Number of pages4
JournalJournal of Virology
Volume78
Issue number20
DOIs
Publication statusPublished - 1 Oct 2004

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ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Insect Science
  • Virology

Cite this

Rowe, T., Gao, G., Hogan, R. J., Crystal, R. G., Voss, T. G., Grant, R. L., Bell, P., Kobinger, G. P., Wivel, N. A., & Wilson, J. M. (2004). Macaque model for severe acute respiratory syndrome. Journal of Virology, 78(20), 11401-11404. https://doi.org/10.1128/JVI.78.20.11401-11404.2004