Lymphocyte mitogenesis, immunoglobulin and complement levels in depressed patients and normal controls

Ziad Kronfol, J. D. House

Research output: Contribution to journalArticle

108 Citations (Scopus)

Abstract

The central nervous system and the immune system are closely related. Psychiatric illness is often associated with a dysregulation of the immune response. In an attempt to expand on previously reported immune abnormalities in patients with depressive illness, we compared several immune measures in a group of hospitalized depressed patients and healthy normal controls. Depressed patients had significantly higher percentages of circulating neutrophils, significantly lower percentages of circulating lymphocytes and significantly lower in vitro lymphocyte responses to mitogenic stimulation than normal controls. Basal plasma cortisol and circulating levels of the complement components C3 and C4 were also higher in the depressed group. We also found a significant association between cortisol values and the traffic of leukocytes on the one hand, and complement levels and the lymphocyte mitogenic activities on the other. These findings expand previously reported evidence of immune abnormalities in depressive illness and provide a partial explanation for some of these findings.

Original languageEnglish
Pages (from-to)142-147
Number of pages6
JournalActa Psychiatrica Scandinavica
Volume80
Issue number2
DOIs
Publication statusPublished - 1989
Externally publishedYes

Fingerprint

Immunoglobulins
Lymphocytes
Hydrocortisone
Complement C4
Complement C3
Psychiatry
Immune System
Neutrophils
Leukocytes
Central Nervous System
In Vitro Techniques

Keywords

  • affective disorder
  • complement
  • depression
  • immunity
  • lymphocyte

ASJC Scopus subject areas

  • Medicine(all)
  • Psychiatry and Mental health

Cite this

Lymphocyte mitogenesis, immunoglobulin and complement levels in depressed patients and normal controls. / Kronfol, Ziad; House, J. D.

In: Acta Psychiatrica Scandinavica, Vol. 80, No. 2, 1989, p. 142-147.

Research output: Contribution to journalArticle

@article{2fd6b30f80b84ada824a32f1e370e298,
title = "Lymphocyte mitogenesis, immunoglobulin and complement levels in depressed patients and normal controls",
abstract = "The central nervous system and the immune system are closely related. Psychiatric illness is often associated with a dysregulation of the immune response. In an attempt to expand on previously reported immune abnormalities in patients with depressive illness, we compared several immune measures in a group of hospitalized depressed patients and healthy normal controls. Depressed patients had significantly higher percentages of circulating neutrophils, significantly lower percentages of circulating lymphocytes and significantly lower in vitro lymphocyte responses to mitogenic stimulation than normal controls. Basal plasma cortisol and circulating levels of the complement components C3 and C4 were also higher in the depressed group. We also found a significant association between cortisol values and the traffic of leukocytes on the one hand, and complement levels and the lymphocyte mitogenic activities on the other. These findings expand previously reported evidence of immune abnormalities in depressive illness and provide a partial explanation for some of these findings.",
keywords = "affective disorder, complement, depression, immunity, lymphocyte",
author = "Ziad Kronfol and House, {J. D.}",
year = "1989",
doi = "10.1111/j.1600-0447.1989.tb01316.x",
language = "English",
volume = "80",
pages = "142--147",
journal = "Acta Psychiatrica Scandinavica",
issn = "0001-690X",
publisher = "Wiley-Blackwell",
number = "2",

}

TY - JOUR

T1 - Lymphocyte mitogenesis, immunoglobulin and complement levels in depressed patients and normal controls

AU - Kronfol, Ziad

AU - House, J. D.

PY - 1989

Y1 - 1989

N2 - The central nervous system and the immune system are closely related. Psychiatric illness is often associated with a dysregulation of the immune response. In an attempt to expand on previously reported immune abnormalities in patients with depressive illness, we compared several immune measures in a group of hospitalized depressed patients and healthy normal controls. Depressed patients had significantly higher percentages of circulating neutrophils, significantly lower percentages of circulating lymphocytes and significantly lower in vitro lymphocyte responses to mitogenic stimulation than normal controls. Basal plasma cortisol and circulating levels of the complement components C3 and C4 were also higher in the depressed group. We also found a significant association between cortisol values and the traffic of leukocytes on the one hand, and complement levels and the lymphocyte mitogenic activities on the other. These findings expand previously reported evidence of immune abnormalities in depressive illness and provide a partial explanation for some of these findings.

AB - The central nervous system and the immune system are closely related. Psychiatric illness is often associated with a dysregulation of the immune response. In an attempt to expand on previously reported immune abnormalities in patients with depressive illness, we compared several immune measures in a group of hospitalized depressed patients and healthy normal controls. Depressed patients had significantly higher percentages of circulating neutrophils, significantly lower percentages of circulating lymphocytes and significantly lower in vitro lymphocyte responses to mitogenic stimulation than normal controls. Basal plasma cortisol and circulating levels of the complement components C3 and C4 were also higher in the depressed group. We also found a significant association between cortisol values and the traffic of leukocytes on the one hand, and complement levels and the lymphocyte mitogenic activities on the other. These findings expand previously reported evidence of immune abnormalities in depressive illness and provide a partial explanation for some of these findings.

KW - affective disorder

KW - complement

KW - depression

KW - immunity

KW - lymphocyte

UR - http://www.scopus.com/inward/record.url?scp=0024450810&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0024450810&partnerID=8YFLogxK

U2 - 10.1111/j.1600-0447.1989.tb01316.x

DO - 10.1111/j.1600-0447.1989.tb01316.x

M3 - Article

VL - 80

SP - 142

EP - 147

JO - Acta Psychiatrica Scandinavica

JF - Acta Psychiatrica Scandinavica

SN - 0001-690X

IS - 2

ER -