Lung growth after unilateral pneumonectomy: quantitation of collagen synthesis and content

M. J. Cowan, Ronald Crystal

Research output: Contribution to journalArticle

51 Citations (Scopus)

Abstract

Unilateral pneumonectomy in the adult rabbit causes the mass of the remaining lung to double within 1 mth. The content and synthesis of lung collagen were compared in 113 rabbits with pneumonectomy, thoracotomy without pneumonectomy, or pneumonectomy with subsequent wax plombage. By the 28th day after left pneumonectomy, total lung collagen and cell number were nearly 100% greater than matched control values, but the density of both collagen and cell number remained constant and unchanged from control. This collagen accumulation was preceded by an increase in the rate of collagen synthesis per cell and in the percent of lung total protein synthesis represented by collagen synthesis. In normal neonatal lung growth, total lung mass, collagen, and cell number increase. During this same period there is also an increase in the % of collagen synthesis represented by lung total protein synthesis; however, in contrast to postpneumonectomy adult lung growth, the density of collagen increases. Obliteration of the empty hemithorax with wax after pneumonectomy resulted in suppression of the increases in right lung cell number, collagen synthesis, and collagen accumulation seen with pneumonectomy alone. This could have generalized implications relating to the control of lung gene expression in that lung cell replication and/or lung cell differentiation may, in part, be controlled by the available space into which the lung may grow.

Original languageEnglish
Pages (from-to)267-277
Number of pages11
JournalAMER.REV.RESP.DIS.
Volume111
Issue number3
Publication statusPublished - 1 Dec 1975
Externally publishedYes

Fingerprint

Pneumonectomy
Collagen
Lung
Growth
Cell Count
Waxes
Rabbits
Thoracotomy
Cell Differentiation
Proteins

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Lung growth after unilateral pneumonectomy : quantitation of collagen synthesis and content. / Cowan, M. J.; Crystal, Ronald.

In: AMER.REV.RESP.DIS., Vol. 111, No. 3, 01.12.1975, p. 267-277.

Research output: Contribution to journalArticle

@article{94342f291e6f4a1d979a9eef101ffabf,
title = "Lung growth after unilateral pneumonectomy: quantitation of collagen synthesis and content",
abstract = "Unilateral pneumonectomy in the adult rabbit causes the mass of the remaining lung to double within 1 mth. The content and synthesis of lung collagen were compared in 113 rabbits with pneumonectomy, thoracotomy without pneumonectomy, or pneumonectomy with subsequent wax plombage. By the 28th day after left pneumonectomy, total lung collagen and cell number were nearly 100{\%} greater than matched control values, but the density of both collagen and cell number remained constant and unchanged from control. This collagen accumulation was preceded by an increase in the rate of collagen synthesis per cell and in the percent of lung total protein synthesis represented by collagen synthesis. In normal neonatal lung growth, total lung mass, collagen, and cell number increase. During this same period there is also an increase in the {\%} of collagen synthesis represented by lung total protein synthesis; however, in contrast to postpneumonectomy adult lung growth, the density of collagen increases. Obliteration of the empty hemithorax with wax after pneumonectomy resulted in suppression of the increases in right lung cell number, collagen synthesis, and collagen accumulation seen with pneumonectomy alone. This could have generalized implications relating to the control of lung gene expression in that lung cell replication and/or lung cell differentiation may, in part, be controlled by the available space into which the lung may grow.",
author = "Cowan, {M. J.} and Ronald Crystal",
year = "1975",
month = "12",
day = "1",
language = "English",
volume = "111",
pages = "267--277",
journal = "American Journal of Respiratory and Critical Care Medicine",
issn = "1073-449X",
publisher = "American Thoracic Society",
number = "3",

}

TY - JOUR

T1 - Lung growth after unilateral pneumonectomy

T2 - quantitation of collagen synthesis and content

AU - Cowan, M. J.

AU - Crystal, Ronald

PY - 1975/12/1

Y1 - 1975/12/1

N2 - Unilateral pneumonectomy in the adult rabbit causes the mass of the remaining lung to double within 1 mth. The content and synthesis of lung collagen were compared in 113 rabbits with pneumonectomy, thoracotomy without pneumonectomy, or pneumonectomy with subsequent wax plombage. By the 28th day after left pneumonectomy, total lung collagen and cell number were nearly 100% greater than matched control values, but the density of both collagen and cell number remained constant and unchanged from control. This collagen accumulation was preceded by an increase in the rate of collagen synthesis per cell and in the percent of lung total protein synthesis represented by collagen synthesis. In normal neonatal lung growth, total lung mass, collagen, and cell number increase. During this same period there is also an increase in the % of collagen synthesis represented by lung total protein synthesis; however, in contrast to postpneumonectomy adult lung growth, the density of collagen increases. Obliteration of the empty hemithorax with wax after pneumonectomy resulted in suppression of the increases in right lung cell number, collagen synthesis, and collagen accumulation seen with pneumonectomy alone. This could have generalized implications relating to the control of lung gene expression in that lung cell replication and/or lung cell differentiation may, in part, be controlled by the available space into which the lung may grow.

AB - Unilateral pneumonectomy in the adult rabbit causes the mass of the remaining lung to double within 1 mth. The content and synthesis of lung collagen were compared in 113 rabbits with pneumonectomy, thoracotomy without pneumonectomy, or pneumonectomy with subsequent wax plombage. By the 28th day after left pneumonectomy, total lung collagen and cell number were nearly 100% greater than matched control values, but the density of both collagen and cell number remained constant and unchanged from control. This collagen accumulation was preceded by an increase in the rate of collagen synthesis per cell and in the percent of lung total protein synthesis represented by collagen synthesis. In normal neonatal lung growth, total lung mass, collagen, and cell number increase. During this same period there is also an increase in the % of collagen synthesis represented by lung total protein synthesis; however, in contrast to postpneumonectomy adult lung growth, the density of collagen increases. Obliteration of the empty hemithorax with wax after pneumonectomy resulted in suppression of the increases in right lung cell number, collagen synthesis, and collagen accumulation seen with pneumonectomy alone. This could have generalized implications relating to the control of lung gene expression in that lung cell replication and/or lung cell differentiation may, in part, be controlled by the available space into which the lung may grow.

UR - http://www.scopus.com/inward/record.url?scp=0016635315&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0016635315&partnerID=8YFLogxK

M3 - Article

C2 - 1119740

AN - SCOPUS:0016635315

VL - 111

SP - 267

EP - 277

JO - American Journal of Respiratory and Critical Care Medicine

JF - American Journal of Respiratory and Critical Care Medicine

SN - 1073-449X

IS - 3

ER -