Lung collagen

definition, diversity and development

Research output: Contribution to journalReview article

26 Citations (Scopus)

Abstract

Morphologic studies demonstrate collagen as a major component of the tracheobronchial tree, vascular tree, and alveolar interstitium. Functional studies suggest it is an important determinant of lung mechanics and structural stability. Although it comprises 10-15% of the dry weight of the adult lung, it is very difficult to extract intact, presumably because of cross links among collagen chains and the association of collagen with other lung components. Short term explant cultures of different lung structures synthesize collagen α chains which can be extracted and purified. Although there is some overlap, the tracheobronchial tree, vascular tree, and peripheral lung synthesize structurally different α chains, all with mol wt of 100,000 daltons. The mechanisms of collagen synthesis and modification in lung are similar to those elsewhere in the body. However, there are variations in the control of lung collagen synthesis that have major importance for this organ. After birth, there is a rapid increase in both the total amount and concentration of collagen in lung. This is accompanied by a shift in the emphasis of the protein synthesizing machinery of lung toward collagen synthesis. In the adult lung, however, collagen synthesis is at a constant low level. In the rabbit, this can be modified by performing unilateral pneumonectomy. The subsequent rapid growth of the remaining lung includes an accumulation of collagen preceded by a shift in protein synthesis toward collagen synthesis. Continued application of the technologies of protein chemistry, molecular biology and tissue culture to these problems should allow substantial progress in understanding the biochemical basis of pulmonary function.

Original languageEnglish
Pages (from-to)2248-2255
Number of pages8
JournalFederation Proceedings
Volume33
Issue number11
Publication statusPublished - 1 Dec 1974
Externally publishedYes

Fingerprint

Collagen
Lung
Blood Vessels
Proteins
Pneumonectomy
Mechanics
Molecular Biology
Parturition
Rabbits
Technology
Weights and Measures
Growth

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Lung collagen : definition, diversity and development. / Crystal, Ronald.

In: Federation Proceedings, Vol. 33, No. 11, 01.12.1974, p. 2248-2255.

Research output: Contribution to journalReview article

@article{3dd6babcadc94616808e315bf7598106,
title = "Lung collagen: definition, diversity and development",
abstract = "Morphologic studies demonstrate collagen as a major component of the tracheobronchial tree, vascular tree, and alveolar interstitium. Functional studies suggest it is an important determinant of lung mechanics and structural stability. Although it comprises 10-15{\%} of the dry weight of the adult lung, it is very difficult to extract intact, presumably because of cross links among collagen chains and the association of collagen with other lung components. Short term explant cultures of different lung structures synthesize collagen α chains which can be extracted and purified. Although there is some overlap, the tracheobronchial tree, vascular tree, and peripheral lung synthesize structurally different α chains, all with mol wt of 100,000 daltons. The mechanisms of collagen synthesis and modification in lung are similar to those elsewhere in the body. However, there are variations in the control of lung collagen synthesis that have major importance for this organ. After birth, there is a rapid increase in both the total amount and concentration of collagen in lung. This is accompanied by a shift in the emphasis of the protein synthesizing machinery of lung toward collagen synthesis. In the adult lung, however, collagen synthesis is at a constant low level. In the rabbit, this can be modified by performing unilateral pneumonectomy. The subsequent rapid growth of the remaining lung includes an accumulation of collagen preceded by a shift in protein synthesis toward collagen synthesis. Continued application of the technologies of protein chemistry, molecular biology and tissue culture to these problems should allow substantial progress in understanding the biochemical basis of pulmonary function.",
author = "Ronald Crystal",
year = "1974",
month = "12",
day = "1",
language = "English",
volume = "33",
pages = "2248--2255",
journal = "Federation Proceedings",
issn = "0014-9446",
number = "11",

}

TY - JOUR

T1 - Lung collagen

T2 - definition, diversity and development

AU - Crystal, Ronald

PY - 1974/12/1

Y1 - 1974/12/1

N2 - Morphologic studies demonstrate collagen as a major component of the tracheobronchial tree, vascular tree, and alveolar interstitium. Functional studies suggest it is an important determinant of lung mechanics and structural stability. Although it comprises 10-15% of the dry weight of the adult lung, it is very difficult to extract intact, presumably because of cross links among collagen chains and the association of collagen with other lung components. Short term explant cultures of different lung structures synthesize collagen α chains which can be extracted and purified. Although there is some overlap, the tracheobronchial tree, vascular tree, and peripheral lung synthesize structurally different α chains, all with mol wt of 100,000 daltons. The mechanisms of collagen synthesis and modification in lung are similar to those elsewhere in the body. However, there are variations in the control of lung collagen synthesis that have major importance for this organ. After birth, there is a rapid increase in both the total amount and concentration of collagen in lung. This is accompanied by a shift in the emphasis of the protein synthesizing machinery of lung toward collagen synthesis. In the adult lung, however, collagen synthesis is at a constant low level. In the rabbit, this can be modified by performing unilateral pneumonectomy. The subsequent rapid growth of the remaining lung includes an accumulation of collagen preceded by a shift in protein synthesis toward collagen synthesis. Continued application of the technologies of protein chemistry, molecular biology and tissue culture to these problems should allow substantial progress in understanding the biochemical basis of pulmonary function.

AB - Morphologic studies demonstrate collagen as a major component of the tracheobronchial tree, vascular tree, and alveolar interstitium. Functional studies suggest it is an important determinant of lung mechanics and structural stability. Although it comprises 10-15% of the dry weight of the adult lung, it is very difficult to extract intact, presumably because of cross links among collagen chains and the association of collagen with other lung components. Short term explant cultures of different lung structures synthesize collagen α chains which can be extracted and purified. Although there is some overlap, the tracheobronchial tree, vascular tree, and peripheral lung synthesize structurally different α chains, all with mol wt of 100,000 daltons. The mechanisms of collagen synthesis and modification in lung are similar to those elsewhere in the body. However, there are variations in the control of lung collagen synthesis that have major importance for this organ. After birth, there is a rapid increase in both the total amount and concentration of collagen in lung. This is accompanied by a shift in the emphasis of the protein synthesizing machinery of lung toward collagen synthesis. In the adult lung, however, collagen synthesis is at a constant low level. In the rabbit, this can be modified by performing unilateral pneumonectomy. The subsequent rapid growth of the remaining lung includes an accumulation of collagen preceded by a shift in protein synthesis toward collagen synthesis. Continued application of the technologies of protein chemistry, molecular biology and tissue culture to these problems should allow substantial progress in understanding the biochemical basis of pulmonary function.

UR - http://www.scopus.com/inward/record.url?scp=0016326254&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0016326254&partnerID=8YFLogxK

M3 - Review article

VL - 33

SP - 2248

EP - 2255

JO - Federation Proceedings

JF - Federation Proceedings

SN - 0014-9446

IS - 11

ER -