Loss of survivin in neural precursor cells results in impaired long-term potentiation in the dentate gyrus and CA1-region

E. Iscru, Tariq Ahmed, V. Coremans, Y. Bozzi, M. Caleo, E. M. Conway, R. D'Hooge, D. Balschun

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

In adult mammals, newborn neural precursor cells (NPCs) derived from either the subventricular zone (SVZ) or the subgranular zone (SGZ) migrate into the olfactory bulb and the dentate gyrus (DG), respectively, where some of them mature into excitatory and inhibitory neurons. There is increasing evidence that this neurogenesis process is important for some types of learning and synaptic plasticity and vice versa. Survivin, a member of the inhibitor-of-apoptosis protein (IAP) family, has been suggested to have a central role in the regulation of neurogenesis. The protein is abundantly expressed in nervous tissue during embryonic development while being restricted postnatally to proliferating and migrating NPCs in SVZ and SGZ. Here we examined adult. SurvivinCamcre mice with a conditional deletion of the. survivin gene in embryonic neurogenic regions. Although the deletion of survivin had no effect on basic excitability in DG and CA1-region, there was a marked impairment of long-term potentiation (LTP) in these areas. Our data support a function of survivin in hippocampal synaptic plasticity and learning and underline the importance of adult brain neurogenesis for proper operation of the hippocampal tri-synaptic circuit and the physiological functions that depend on it.

Original languageEnglish
Pages (from-to)413-419
Number of pages7
JournalNeuroscience
Volume231
DOIs
Publication statusPublished - 2 Feb 2013
Externally publishedYes

Fingerprint

Long-Term Potentiation
Neurogenesis
Dentate Gyrus
Neuronal Plasticity
Lateral Ventricles
Learning
Inhibitor of Apoptosis Proteins
Nerve Tissue
Olfactory Bulb
Embryonic Development
Mammals
Neurons
Brain
Genes
Proteins

Keywords

  • Dentate gyrus
  • LTP
  • Neurogenesis
  • Picrotoxin
  • Survivin

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Loss of survivin in neural precursor cells results in impaired long-term potentiation in the dentate gyrus and CA1-region. / Iscru, E.; Ahmed, Tariq; Coremans, V.; Bozzi, Y.; Caleo, M.; Conway, E. M.; D'Hooge, R.; Balschun, D.

In: Neuroscience, Vol. 231, 02.02.2013, p. 413-419.

Research output: Contribution to journalArticle

Iscru, E. ; Ahmed, Tariq ; Coremans, V. ; Bozzi, Y. ; Caleo, M. ; Conway, E. M. ; D'Hooge, R. ; Balschun, D. / Loss of survivin in neural precursor cells results in impaired long-term potentiation in the dentate gyrus and CA1-region. In: Neuroscience. 2013 ; Vol. 231. pp. 413-419.
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