Long non-coding RNAs embedded in the Rb and p53 pathways

Murugan Subramanian, Matthew F. Jones, Ashish Lal

Research output: Contribution to journalReview article

22 Citations (Scopus)

Abstract

In recent years, long non-coding RNAs (lncRNAs) have gained significant attention as a novel class of gene regulators. Although a small number of lncRNAs have been shown to regulate gene expression through diverse mechanisms including transcriptional regulation, mRNA splicing and translation, the physiological function and mechanism of action of the vast majority are not known. Profiling studies in cell lines and tumor samples have suggested a potential role of lncRNAs in cancer. Indeed, distinct lncRNAs have been shown to be embedded in the p53 and Rb networks, two of the major tumor suppressor pathways that control cell cycle progression and survival. Given the fact that inactivation of Rb and p53 is a hallmark of human cancer, in this review we discuss recent evidence on the function of lncRNAs in the Rb and p53 signaling pathways.

Original languageEnglish
Pages (from-to)1655-1675
Number of pages21
JournalCancers
Volume5
Issue number4
DOIs
Publication statusPublished - 1 Dec 2013

Keywords

  • Cell cycle
  • Rb
  • lncRNA
  • miRNA
  • p53

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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