Liver transplantation for hepatitis B in the United States

C. Camci, A. Gurakar, J. Rose, S. Rizvi, H. Wright, T. Bader, R. Monlux, R. R. Schade, Bakr Nour, A. Sebastian

Research output: Contribution to journalReview article

14 Citations (Scopus)

Abstract

Aim. To evaluate the impact of hepatitis B virus (HBV) on US health care system, we reviewed the Organ Procurement and Transplantation (OPTN, formerly UNOS) HBV database. Method. We reviewed records of liver transplantations (LTx) performed in the United States listed for the diagnoses of HBV between 1993 and mid-October 2004. Both acute as well as chronic cases were included. Coinfection with hepatitis C virus was excluded from study. The specific states selected for review were chosen from those areas that are receiving large numbers of new immigrants from high HBV endemic areas (ie, Texas, Pennsylvania, California, New York, and Florida). One-, 3-, and 5-year patient survival rates for both cadaveric and living related donors were analyzed. Survival rates were obtained from OPTN database as Kaplan-Meyer survival test. Results. Between 1993 and mid-October 2004, 53,312 LTx had been performed nationwide. Of these, 2314 (4.34%) were performed for the diagnosis of HBV; 1816 cases (78%) were due to chronic HBV infection (45 of them were living donor LTx) and 498 cases (22%) were due to HBV-induced acute liver failure (seven of them were living donor LTx). Three- and 5-year survival rates of chronic HBV-related LTx patients were better than acute HBV-related and overall LTx patients. Conclusion. HBV is generally considered to have a minor health significance by many community gastroenterologists. With growing immigration from overseas, it may eventually have a higher impact on LTx. Therefore, it is crucial to further educate gastroenterologists and primary care physicians caring for this specific group of patients.

Original languageEnglish
Pages (from-to)4350-4353
Number of pages4
JournalTransplantation Proceedings
Volume37
Issue number10
DOIs
Publication statusPublished - Dec 2005
Externally publishedYes

Fingerprint

Hepatitis B
Hepatitis B virus
Liver Transplantation
Living Donors
Survival Rate
Chronic Hepatitis B
Databases
Tissue and Organ Procurement
Acute Liver Failure
Emigration and Immigration
Primary Care Physicians
Organ Transplantation
Virus Diseases
Coinfection
Hepacivirus
Delivery of Health Care
Survival
Health

ASJC Scopus subject areas

  • Surgery
  • Transplantation

Cite this

Camci, C., Gurakar, A., Rose, J., Rizvi, S., Wright, H., Bader, T., ... Sebastian, A. (2005). Liver transplantation for hepatitis B in the United States. Transplantation Proceedings, 37(10), 4350-4353. https://doi.org/10.1016/j.transproceed.2005.10.017

Liver transplantation for hepatitis B in the United States. / Camci, C.; Gurakar, A.; Rose, J.; Rizvi, S.; Wright, H.; Bader, T.; Monlux, R.; Schade, R. R.; Nour, Bakr; Sebastian, A.

In: Transplantation Proceedings, Vol. 37, No. 10, 12.2005, p. 4350-4353.

Research output: Contribution to journalReview article

Camci, C, Gurakar, A, Rose, J, Rizvi, S, Wright, H, Bader, T, Monlux, R, Schade, RR, Nour, B & Sebastian, A 2005, 'Liver transplantation for hepatitis B in the United States', Transplantation Proceedings, vol. 37, no. 10, pp. 4350-4353. https://doi.org/10.1016/j.transproceed.2005.10.017
Camci C, Gurakar A, Rose J, Rizvi S, Wright H, Bader T et al. Liver transplantation for hepatitis B in the United States. Transplantation Proceedings. 2005 Dec;37(10):4350-4353. https://doi.org/10.1016/j.transproceed.2005.10.017
Camci, C. ; Gurakar, A. ; Rose, J. ; Rizvi, S. ; Wright, H. ; Bader, T. ; Monlux, R. ; Schade, R. R. ; Nour, Bakr ; Sebastian, A. / Liver transplantation for hepatitis B in the United States. In: Transplantation Proceedings. 2005 ; Vol. 37, No. 10. pp. 4350-4353.
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abstract = "Aim. To evaluate the impact of hepatitis B virus (HBV) on US health care system, we reviewed the Organ Procurement and Transplantation (OPTN, formerly UNOS) HBV database. Method. We reviewed records of liver transplantations (LTx) performed in the United States listed for the diagnoses of HBV between 1993 and mid-October 2004. Both acute as well as chronic cases were included. Coinfection with hepatitis C virus was excluded from study. The specific states selected for review were chosen from those areas that are receiving large numbers of new immigrants from high HBV endemic areas (ie, Texas, Pennsylvania, California, New York, and Florida). One-, 3-, and 5-year patient survival rates for both cadaveric and living related donors were analyzed. Survival rates were obtained from OPTN database as Kaplan-Meyer survival test. Results. Between 1993 and mid-October 2004, 53,312 LTx had been performed nationwide. Of these, 2314 (4.34{\%}) were performed for the diagnosis of HBV; 1816 cases (78{\%}) were due to chronic HBV infection (45 of them were living donor LTx) and 498 cases (22{\%}) were due to HBV-induced acute liver failure (seven of them were living donor LTx). Three- and 5-year survival rates of chronic HBV-related LTx patients were better than acute HBV-related and overall LTx patients. Conclusion. HBV is generally considered to have a minor health significance by many community gastroenterologists. With growing immigration from overseas, it may eventually have a higher impact on LTx. Therefore, it is crucial to further educate gastroenterologists and primary care physicians caring for this specific group of patients.",
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AU - Bader, T.

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AU - Schade, R. R.

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N2 - Aim. To evaluate the impact of hepatitis B virus (HBV) on US health care system, we reviewed the Organ Procurement and Transplantation (OPTN, formerly UNOS) HBV database. Method. We reviewed records of liver transplantations (LTx) performed in the United States listed for the diagnoses of HBV between 1993 and mid-October 2004. Both acute as well as chronic cases were included. Coinfection with hepatitis C virus was excluded from study. The specific states selected for review were chosen from those areas that are receiving large numbers of new immigrants from high HBV endemic areas (ie, Texas, Pennsylvania, California, New York, and Florida). One-, 3-, and 5-year patient survival rates for both cadaveric and living related donors were analyzed. Survival rates were obtained from OPTN database as Kaplan-Meyer survival test. Results. Between 1993 and mid-October 2004, 53,312 LTx had been performed nationwide. Of these, 2314 (4.34%) were performed for the diagnosis of HBV; 1816 cases (78%) were due to chronic HBV infection (45 of them were living donor LTx) and 498 cases (22%) were due to HBV-induced acute liver failure (seven of them were living donor LTx). Three- and 5-year survival rates of chronic HBV-related LTx patients were better than acute HBV-related and overall LTx patients. Conclusion. HBV is generally considered to have a minor health significance by many community gastroenterologists. With growing immigration from overseas, it may eventually have a higher impact on LTx. Therefore, it is crucial to further educate gastroenterologists and primary care physicians caring for this specific group of patients.

AB - Aim. To evaluate the impact of hepatitis B virus (HBV) on US health care system, we reviewed the Organ Procurement and Transplantation (OPTN, formerly UNOS) HBV database. Method. We reviewed records of liver transplantations (LTx) performed in the United States listed for the diagnoses of HBV between 1993 and mid-October 2004. Both acute as well as chronic cases were included. Coinfection with hepatitis C virus was excluded from study. The specific states selected for review were chosen from those areas that are receiving large numbers of new immigrants from high HBV endemic areas (ie, Texas, Pennsylvania, California, New York, and Florida). One-, 3-, and 5-year patient survival rates for both cadaveric and living related donors were analyzed. Survival rates were obtained from OPTN database as Kaplan-Meyer survival test. Results. Between 1993 and mid-October 2004, 53,312 LTx had been performed nationwide. Of these, 2314 (4.34%) were performed for the diagnosis of HBV; 1816 cases (78%) were due to chronic HBV infection (45 of them were living donor LTx) and 498 cases (22%) were due to HBV-induced acute liver failure (seven of them were living donor LTx). Three- and 5-year survival rates of chronic HBV-related LTx patients were better than acute HBV-related and overall LTx patients. Conclusion. HBV is generally considered to have a minor health significance by many community gastroenterologists. With growing immigration from overseas, it may eventually have a higher impact on LTx. Therefore, it is crucial to further educate gastroenterologists and primary care physicians caring for this specific group of patients.

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