Lipid-modifying activity of curcuminoids: A systematic review and meta-analysis of randomized controlled trials

Luis E. Simental-Mendía, Matteo Pirro, Antonio M. Gotto, Maciej Banach, Stephen Atkin, Muhammed Majeed, Amirhossein Sahebkar

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

OBJECTIVE: The aim of this systematic review and meta-analysis was to determine and clarify the impact of curcuminoids on serum lipid levels. METHODS: Randomized controlled trials (RCTs) investigating the effects of curcuminoids on plasma lipids were searched in PubMed-Medline, Scopus, Web of Science databases (from inception to April 3rd, 2017). A random-effects model and generic inverse variance method were used for quantitative data synthesis. Sensitivity analysis was conducted using the leave-one-out method. A weighted random-effects meta-regression was performed to evaluate the impact of potential confounders on lipid concentrations. RESULTS: A meta-analysis of 20 RCTs with 1427 participants suggested a significant decrease in plasma concentrations of triglycerides (WMD: -21.36 mg/dL, 95% CI: -32.18, -10.53, p < 0.001), and an elevation in plasma HDL-C levels (WMD: 1.42 mg/dL, 95% CI: 0.03, 2.81, p = 0.046), while plasma levels of LDL-C (WMD: -5.82 mg/dL, 95% CI: -15.80, 4.16, p = 0.253) and total cholesterol (WMD: -9.57 mg/dL, 95% CI: -20.89, 1.75, p = 0.098) were not altered. The effects of curcuminoids on lipids were not found to be dependent on the duration of supplementation. CONCLUSION: This meta-analysis has shown that curcuminoid therapy significantly reduces plasma triglycerides and increases HDL-C levels.

Original languageEnglish
Pages (from-to)1178-1187
Number of pages10
JournalCritical reviews in food science and nutrition
Volume59
Issue number7
DOIs
Publication statusPublished - 1 Jan 2019

Fingerprint

systematic review
meta-analysis
Lipids
Meta-Analysis
Randomized Controlled Trials
Plasmas
blood lipids
lipids
triacylglycerols
Triglycerides
cholesterol
Cholesterol
therapeutics
synthesis
duration
PubMed
Sensitivity analysis
methodology
Databases
Serum

Keywords

  • Cardiovascular disease
  • Cholesterol
  • Curcumin
  • Dyslipidemia
  • Triglycerides
  • Turmeric

ASJC Scopus subject areas

  • Food Science
  • Industrial and Manufacturing Engineering

Cite this

Lipid-modifying activity of curcuminoids : A systematic review and meta-analysis of randomized controlled trials. / Simental-Mendía, Luis E.; Pirro, Matteo; Gotto, Antonio M.; Banach, Maciej; Atkin, Stephen; Majeed, Muhammed; Sahebkar, Amirhossein.

In: Critical reviews in food science and nutrition, Vol. 59, No. 7, 01.01.2019, p. 1178-1187.

Research output: Contribution to journalArticle

Simental-Mendía, Luis E. ; Pirro, Matteo ; Gotto, Antonio M. ; Banach, Maciej ; Atkin, Stephen ; Majeed, Muhammed ; Sahebkar, Amirhossein. / Lipid-modifying activity of curcuminoids : A systematic review and meta-analysis of randomized controlled trials. In: Critical reviews in food science and nutrition. 2019 ; Vol. 59, No. 7. pp. 1178-1187.
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