Abstract
We have conducted, in 64 affected families, a study of linkage between the anonymous DNA segment pB79a (D7S13) and the locus for cystic fibrosis (CF) on chromosome 7q. The maximum lod score was 12.60 at θ = .08 (confidence bounds .045-.135). Although D7S13 is not sufficiently close to CF for routine use in DNA-based prenatal diagnosis, it will be helpful in certain families when other nearby markers are uninformative. D7S13 will also be useful for refining the linkage map of the CF region.
| Original language | English |
|---|---|
| Pages (from-to) | 944-947 |
| Number of pages | 4 |
| Journal | American Journal of Human Genetics |
| Volume | 41 |
| Issue number | 5 |
| Publication status | Published - 1 Dec 1987 |
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ASJC Scopus subject areas
- Genetics
- Genetics(clinical)
Cite this
Wainwright, B. J., Tsui, L. C., Leppert, M., Buchwald, M., Estivill, X., O'Connell, P., Lathrop, M., LaLouel, J. M., White, R., Williamson, R., & Farrall, M. (1987). Linkage of DNA probe B79a (D7S13) to cystic fibrosis. American Journal of Human Genetics, 41(5), 944-947.