Linkage of DNA probe B79a (D7S13) to cystic fibrosis

B. J. Wainwright, L. C. Tsui, M. Leppert, M. Buchwald, Xavier P. Estivill, P. O'Connell, M. Lathrop, J. M. LaLouel, R. White, R. Williamson, M. Farrall

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

We have conducted, in 64 affected families, a study of linkage between the anonymous DNA segment pB79a (D7S13) and the locus for cystic fibrosis (CF) on chromosome 7q. The maximum lod score was 12.60 at θ = .08 (confidence bounds .045-.135). Although D7S13 is not sufficiently close to CF for routine use in DNA-based prenatal diagnosis, it will be helpful in certain families when other nearby markers are uninformative. D7S13 will also be useful for refining the linkage map of the CF region.

Original languageEnglish
Pages (from-to)944-947
Number of pages4
JournalAmerican Journal of Human Genetics
Volume41
Issue number5
Publication statusPublished - 1987
Externally publishedYes

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DNA Probes
Cystic Fibrosis
Lod Score
DNA
Prenatal Diagnosis
Chromosomes

ASJC Scopus subject areas

  • Genetics

Cite this

Wainwright, B. J., Tsui, L. C., Leppert, M., Buchwald, M., Estivill, X. P., O'Connell, P., ... Farrall, M. (1987). Linkage of DNA probe B79a (D7S13) to cystic fibrosis. American Journal of Human Genetics, 41(5), 944-947.

Linkage of DNA probe B79a (D7S13) to cystic fibrosis. / Wainwright, B. J.; Tsui, L. C.; Leppert, M.; Buchwald, M.; Estivill, Xavier P.; O'Connell, P.; Lathrop, M.; LaLouel, J. M.; White, R.; Williamson, R.; Farrall, M.

In: American Journal of Human Genetics, Vol. 41, No. 5, 1987, p. 944-947.

Research output: Contribution to journalArticle

Wainwright, BJ, Tsui, LC, Leppert, M, Buchwald, M, Estivill, XP, O'Connell, P, Lathrop, M, LaLouel, JM, White, R, Williamson, R & Farrall, M 1987, 'Linkage of DNA probe B79a (D7S13) to cystic fibrosis', American Journal of Human Genetics, vol. 41, no. 5, pp. 944-947.
Wainwright BJ, Tsui LC, Leppert M, Buchwald M, Estivill XP, O'Connell P et al. Linkage of DNA probe B79a (D7S13) to cystic fibrosis. American Journal of Human Genetics. 1987;41(5):944-947.
Wainwright, B. J. ; Tsui, L. C. ; Leppert, M. ; Buchwald, M. ; Estivill, Xavier P. ; O'Connell, P. ; Lathrop, M. ; LaLouel, J. M. ; White, R. ; Williamson, R. ; Farrall, M. / Linkage of DNA probe B79a (D7S13) to cystic fibrosis. In: American Journal of Human Genetics. 1987 ; Vol. 41, No. 5. pp. 944-947.
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