Abstract
We have conducted, in 64 affected families, a study of linkage between the anonymous DNA segment pB79a (D7S13) and the locus for cystic fibrosis (CF) on chromosome 7q. The maximum lod score was 12.60 at θ = .08 (confidence bounds .045-.135). Although D7S13 is not sufficiently close to CF for routine use in DNA-based prenatal diagnosis, it will be helpful in certain families when other nearby markers are uninformative. D7S13 will also be useful for refining the linkage map of the CF region.
| Original language | English |
|---|---|
| Pages (from-to) | 944-947 |
| Number of pages | 4 |
| Journal | American Journal of Human Genetics |
| Volume | 41 |
| Issue number | 5 |
| Publication status | Published - 1987 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Genetics
Cite this
Linkage of DNA probe B79a (D7S13) to cystic fibrosis. / Wainwright, B. J.; Tsui, L. C.; Leppert, M.; Buchwald, M.; Estivill, Xavier P.; O'Connell, P.; Lathrop, M.; LaLouel, J. M.; White, R.; Williamson, R.; Farrall, M.
In: American Journal of Human Genetics, Vol. 41, No. 5, 1987, p. 944-947.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Linkage of DNA probe B79a (D7S13) to cystic fibrosis
AU - Wainwright, B. J.
AU - Tsui, L. C.
AU - Leppert, M.
AU - Buchwald, M.
AU - Estivill, Xavier P.
AU - O'Connell, P.
AU - Lathrop, M.
AU - LaLouel, J. M.
AU - White, R.
AU - Williamson, R.
AU - Farrall, M.
PY - 1987
Y1 - 1987
N2 - We have conducted, in 64 affected families, a study of linkage between the anonymous DNA segment pB79a (D7S13) and the locus for cystic fibrosis (CF) on chromosome 7q. The maximum lod score was 12.60 at θ = .08 (confidence bounds .045-.135). Although D7S13 is not sufficiently close to CF for routine use in DNA-based prenatal diagnosis, it will be helpful in certain families when other nearby markers are uninformative. D7S13 will also be useful for refining the linkage map of the CF region.
AB - We have conducted, in 64 affected families, a study of linkage between the anonymous DNA segment pB79a (D7S13) and the locus for cystic fibrosis (CF) on chromosome 7q. The maximum lod score was 12.60 at θ = .08 (confidence bounds .045-.135). Although D7S13 is not sufficiently close to CF for routine use in DNA-based prenatal diagnosis, it will be helpful in certain families when other nearby markers are uninformative. D7S13 will also be useful for refining the linkage map of the CF region.
UR - http://www.scopus.com/inward/record.url?scp=0023634434&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0023634434&partnerID=8YFLogxK
M3 - Article
VL - 41
SP - 944
EP - 947
JO - American Journal of Human Genetics
JF - American Journal of Human Genetics
SN - 0002-9297
IS - 5
ER -