Linkage disequilibrium for DNA haplotypes near the cystic fibrosis locus in two South European populations

Xavier P. Estivill, P. Gasparini, G. Novelli, T. Casals, V. Nunes, P. Gallano, A. Savoia, A. Ruzzo, B. Dallapiccola, P. F. Pignatti

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Abstract

Three polymorphic DNA marker loci (INT1L1, D7S23 and D7S399) map to a chromosomal region that is very close to the cystic fibrosis (CF) locus in terms of genetic distance. These marker loci have been used to analyse the linkage disequilibrium in 137CF families from two South European countries (Italy and Spain). The markers can be analysed for differences in linkage disequilibrium more easily in these populations than in North Europeans, in whom the disequilibrium between the allelic systems defined by the probes and CF is much greater and on a "plateau" through the genetic region. The different levels of disequilibrium found in the studied populations suggest that D7S399 and D7S23 are both closer to CF than INT1L1, and provide additional information on the origins and homogeneity of the CF defect.

Original languageEnglish
Pages (from-to)175-178
Number of pages4
JournalHuman Genetics
Volume83
Issue number2
DOIs
Publication statusPublished - Sep 1989
Externally publishedYes

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ASJC Scopus subject areas

  • Genetics(clinical)
  • Genetics

Cite this

Estivill, X. P., Gasparini, P., Novelli, G., Casals, T., Nunes, V., Gallano, P., Savoia, A., Ruzzo, A., Dallapiccola, B., & Pignatti, P. F. (1989). Linkage disequilibrium for DNA haplotypes near the cystic fibrosis locus in two South European populations. Human Genetics, 83(2), 175-178. https://doi.org/10.1007/BF00286713